"... We developed a detailed biophysical model of STDP and found
that the model required spike timing-dependent distinct suppression of NMDARs by Ca2+-calmodulin.
This led us to predict an allosteric
kinetics of NMDARs: a slow and rapid suppression of NMDARs by Ca2+-calmodulin with prespiking -> postspiking and postspiking -> prespiking, respectively.
We found that the allosteric kinetics, but not the conventional kinetics, is consistent with specific features of
amplitudes and peak time of NMDAR-mediated EPSPs in experiments.
..." See paper for more and details.
Reference:
1 .
Urakubo H, Honda M, Froemke RC, Kuroda S (2008) Requirement of an allosteric kinetics of NMDA receptors for spike timing-dependent plasticity. J Neurosci 28:3310-23 [PubMed]
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