Using experiments in conjunction with this simplified model, we sought to understand the basic mechanisms behind NMDA-induced oscillations in lamprey locomotor neurons, specifically (a) how the oscillation frequency depends on NMDA concentration and why, and (b) what the minimal number of components for generating NMDA oscillations is (in vitro and in the model).
Reference:
1 .
Huss M, Wang D, Trané C, Wikström M, Hellgren Kotaleski J (2008) An experimentally constrained computational model of NMDA oscillations in lamprey CPG neurons. J Comput Neurosci 25:108-21 [PubMed]
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