Efffect of propofol on potassium current in cardiac H9c2 cells (Liu et al. 2008)

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"... The effects of propofol, an intravenous anesthetic agent with a distinct chemical structure, on ion currents of differentiated clonal cardiac (H9c2) cells were investigated in this study. Propofol ... suppressed the amplitude of delayed rectifier K(+) current (I(K(DR))) in a concentration-dependent manner with an IC(50) value of 36 muM. ... Propofol (30 muM) had no effect on erg-mediated K(+) current in these cells; however, it suppressed L-type Ca(2+) current (I(Ca,L)) of cardiac and skeletal types to a similar extent. ... Numerical simulations of I(K(DR)) based on a Markovian model reproduce the experimental results and show that propofol-induced blockade of I(K(DR)) is associated with an decrease in forward rate of the activation process and an increase in transitional rate into the inactivated state. ..."
1 . Liu YC, Wang YJ, Wu SN (2008) The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells. Eur J Pharmacol 590:93-8 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Heart cell;
Channel(s): I Potassium; I_Ks;
Gap Junctions:
Simulation Environment: XPP;
Model Concept(s): Ion Channel Kinetics; Heart disease;
Search NeuronDB for information about:  I Potassium; I_Ks;
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