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CaMKII system exhibiting bistability with respect to calcium (Graupner and Brunel 2007)
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"... We present a detailed biochemical model of the CaMKII autophosphorylation and the protein signaling cascade governing the CaMKII dephosphorylation. ... it is shown that the CaMKII system can qualitatively reproduce results of plasticity outcomes in response to spike-timing dependent plasticity (STDP) and presynaptic stimulation protocols. This shows that the CaMKII protein network can account for both induction, through LTP/LTD-like transitions, and storage, due to its bistability, of synaptic changes."
Graupner M, Brunel N (2007) STDP in a bistable synapse model based on CaMKII and associated signaling pathways.
PLoS Comput Biol
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Hippocampus CA1 pyramidal GLU cell;
Detailed Neuronal Models;
Long-term Synaptic Plasticity;
Graupner, Michael [michael.graupner at ens.fr];
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Hippocampus CA1 pyramidal GLU cell
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