ModelDB: A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)

A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)

Download zip file
Help downloading and running models

Model Information
Model File
Citations

Accession:116575

The leech C-interneuron and its electrical synapse with the S-interneuron exhibit unusual properties: an asymmetric delay when impulses travel from one soma to the other, and graded C-interneuron impulse amplitudes under elevated divalent cation concentrations. These properties have been simulated using a SNNAP model in which the C-interneuron has multiple, independent spike initiation zones associated with individual electrical junctions with the C-interneuron.
Reference:
1 . Crisp KM (2009) Multiple spike initiation zones in a neuron implicated in learning in the leech: a computational model. Invert Neurosci 9:1-10 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Leech C interneuron;
Channel(s):	I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium;
Gap Junctions:	Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	SNNAP;
Model Concept(s):	Action Potential Initiation; Action Potentials;
Implementer(s):	Crisp, Kevin [crisp at stolaf.edu];

Search NeuronDB for information about: I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium; Glutamate;

Download the displayed file

1.8mM_ADP.vdg *

1.8mM_divalents.sm *

25mM_divalents.sm

divalentsCa.fBR

Figure2.smu.exec

Figure2.smu.hmn

Figure2.smu.ing

Figure2.smu.out.head

S_ExcitableNeurite_1.8mM.neu

SNNAP_CCell.bas

Stim_S_Rec_C.ous

Stim_S_Rec_C.ous.mnu

Stim_S_Rec_C.trt

Stim_S_Stim_C.ous

Stim_S_Stim_C.ous.mnu

Stim_S_Stim_C.trt

time<{ivr} 0.0 0.25000000000010925
V[S....]<{ivr} -58.77157941134566 43.72771990142642
V[C....]<{svr} -48.0 3.0853879532972117
sIex[S....]<{ivr} 0.0 15.0
sIex[C....]<{ivr} 0.0 15.0

Loading data, please wait...