Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)

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Accession:116606
"Biophysical properties of neurons contributing to the ability of an animal to decide whether or not to respond were examined. B31/B32, two pairs of bilaterally symmetrical Aplysia neurons, are major participants in deciding to initiate a buccal motor program, the neural correlate of a consummatory feeding response. B31/B32 respond to an adequate stimulus after a delay, during which time additional stimuli influence the decision to respond. B31/B32 then respond with a ramp depolarization followed by a sustained soma depolarization and axon spiking that is the expression of a commitment to respond to food. Four currents contributing to decision making in B31/B32 were characterized, and their functional effects were determined, in current- and voltage-clamp experiments and with simulations. ... Hodgkin-Huxley kinetic analyses were performed on the outward currents. Simulations using equations from these analyses showed that IK-V and IK-A slow the ramp depolarization preceding the sustained depolarization. The three outward currents contribute to braking the B31/B32 depolarization and keeping the sustained depolarization at a constant voltage. The currents identified are sufficient to explain the properties of B31/B32 that play a role in generating the decision to feed."
Reference:
1 . Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ (2008) Currents contributing to decision making in neurons B31/B32 of Aplysia. J Neurophysiol 99:814-30 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Aplysia;
Cell Type(s): Aplysia B31/B32 neuron;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Action Selection/Decision Making;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K;
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hurwitzEtAl2008
with_all_currents_fast_stimulus
B_B63_K.a *
B_B63_K.b *
B_B63_Na.A *
B_B63_Na.B *
b31_axon.neu *
B31_axon_2_Soma.es *
b31_axon_K.vdg *
b31_axon_K2.vdg *
b31_axon_leak.vdg *
b31_axon_Na.vdg *
b31_leak_fixed.vdg *
b31_leak_only.neu *
b31_soma_K1.A *
b31_soma_K1.B *
b31_soma_K1.vdg *
b31_soma_K2.A *
b31_soma_K2.B *
b31_soma_K2.vdg *
b31_soma_K3.A *
b31_soma_K3.B *
b31_soma_K3.vdg *
b31_with_axon.ntw *
b31_with_axon.ous
b31_with_axon.ous.mnu
b31_with_axon.smu
b31_with_axon.smu.exec
b31_with_axon.smu.hmn
b31_with_axon.smu.ing
b31_with_axon.trt
b31_with_axon_vc.trt *
b31_with_axon_with_I_del.ous *
ousgrf.def *
simufiles.usd
                            
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		>>    MODELE NAME: neu		>>
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>------------------------------->--------------------------------------->
   THRESHOLD:	0.0       	> Threshold for transmitter release	>
>------------------------------->--------------------------------------->
   SPIKDUR:	0.003     	> Spike duration. If equal 0 then	>
				>	actual time when presynaptic	>
				>	neuronis above threshold will	>
				>	be measured			>
>------------------------------->--------------------------------------->
   VMINIT:	-60.0     	> Initial value of membrane potential.	>
>------------------------------->--------------------------------------->
   CM:		0.011     	> Membrane capacitance.			>
>------------------------------->--------------------------------------->

>------------------------------->--------------------------------------->
   MEM_AREA:        		>     Membrane Area options		>
>------------------------------->--------------------------------------->
	0			>     do not use membrane area		>
>------------------------------->--------------------------------------->
>	1			>     specify membrane area directly	>
>	5.0             >S<     >     um2				>
>------------------------------->--------------------------------------->
>	2			>     sphere				>
>	20.0            >D<     >     um, diameter			>
>	1.0             >C<     >     invagination factor		>
>------------------------------->--------------------------------------->
>	3			>     cylinder				>
>	3.0             >D<     >     diameter				>
>	30.0            >L<     >     um, length			>
>	0		>n<     >     number of ends closed		>
>	1.0             >C<     >     invagination factor		>
>------------------------------->--------------------------------------->
>	        membrane area is not used				>
>------------------------------->--------------------------------------->


>------------------------------->------------------------------->
   CONDUCTANCES:		>	List of Conductances	>
>------------------------------->------------------------------->
	b31_del_rec		>	Name of conductance	>
	b31_soma_K1.vdg		>	File Name		>
	white			>	Color			>
>------------------------------->------------------------------->
	Leak			>	Name of conductance	>
	b31_leak_fixed.vdg	>	File Name		>
	green			>	Color			>
>------------------------------->------------------------------->
	b31_A_current		>	Name of conductance	>
	b31_soma_K2.vdg		>	File Name		>
	red			>	Color			>
>------------------------------->------------------------------->
	maintained		>	Name of conductance	>
	b31_soma_K3.vdg		>	File Name		>
	blue			>	Color			>
>------------------------------->------------------------------->
	END			>				>
>------------------------------->------------------------------->


END

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