Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)

 Download zip file 
Help downloading and running models
Accession:116606
"Biophysical properties of neurons contributing to the ability of an animal to decide whether or not to respond were examined. B31/B32, two pairs of bilaterally symmetrical Aplysia neurons, are major participants in deciding to initiate a buccal motor program, the neural correlate of a consummatory feeding response. B31/B32 respond to an adequate stimulus after a delay, during which time additional stimuli influence the decision to respond. B31/B32 then respond with a ramp depolarization followed by a sustained soma depolarization and axon spiking that is the expression of a commitment to respond to food. Four currents contributing to decision making in B31/B32 were characterized, and their functional effects were determined, in current- and voltage-clamp experiments and with simulations. ... Hodgkin-Huxley kinetic analyses were performed on the outward currents. Simulations using equations from these analyses showed that IK-V and IK-A slow the ramp depolarization preceding the sustained depolarization. The three outward currents contribute to braking the B31/B32 depolarization and keeping the sustained depolarization at a constant voltage. The currents identified are sufficient to explain the properties of B31/B32 that play a role in generating the decision to feed."
Reference:
1 . Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ (2008) Currents contributing to decision making in neurons B31/B32 of Aplysia. J Neurophysiol 99:814-30 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Aplysia;
Cell Type(s): Aplysia B31/B32 neuron;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Action Selection/Decision Making;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K;
/
hurwitzEtAl2008
with_all_currents_fast_stimulus
B_B63_K.a *
B_B63_K.b *
B_B63_Na.A *
B_B63_Na.B *
b31_axon.neu *
B31_axon_2_Soma.es *
b31_axon_K.vdg *
b31_axon_K2.vdg *
b31_axon_leak.vdg *
b31_axon_Na.vdg *
b31_leak_fixed.vdg *
b31_leak_only.neu *
b31_soma_K1.A *
b31_soma_K1.B *
b31_soma_K1.vdg *
b31_soma_K2.A *
b31_soma_K2.B *
b31_soma_K2.vdg *
b31_soma_K3.A *
b31_soma_K3.B *
b31_soma_K3.vdg *
b31_with_axon.ntw *
b31_with_axon.ous
b31_with_axon.ous.mnu
b31_with_axon.smu
b31_with_axon.smu.exec
b31_with_axon.smu.hmn
b31_with_axon.smu.ing
b31_with_axon.trt
b31_with_axon_vc.trt *
b31_with_axon_with_I_del.ous *
ousgrf.def *
simufiles.usd
                            
>------------------------------->--------------------------------------->
  VAR_TO_GRAPH: 		>	List of current contributing	>
				>		to ion pools		>
>------------------------------->--------------------------------------->
	GRPH_CHNL:		>	Graph channel			>
>------------------------------->--------------------------------------->
	1			>	GAIN of Channel			>
	time<{ivr}            	>	Var Name for X-axis		>
		12          	>	Number of Tic Marks		>
		0.00        	>	Min Value of X			>
		12.00       	>	Max Value of X			>
		green        	>	Color of Range			>
V[b31_leak_only....]<{svr}    	>	Var Name for Y-axis		>
		13          	>	Number of Tic Marks		>
		-65.00      	>	Min Value of Y			>
		0.00        	>	Max Value of Y			>
		green         	>	Color of RAnge			>
>------------------------------->--------------------------------------->
	GRPH_CHNL:		>	Graph channel			>
>------------------------------->--------------------------------------->
	1			>	GAIN of Channel			>
	time<{ivr}            	>	Var Name for X-axis		>
		12          	>	Number of Tic Marks		>
		0.00        	>	Min Value of X			>
		12.00       	>	Max Value of X			>
		blue         	>	Color of Range			>
	V[b31_axon....]<{svr} 	>	Var Name for Y-axis		>
		13          	>	Number of Tic Marks		>
		-65.00      	>	Min Value of Y			>
		0.00        	>	Max Value of Y			>
		blue          	>	Color of RAnge			>
>------------------------------->--------------------------------------->
	END:			>					>
>------------------------------->--------------------------------------->

>------------------------------->--------------------------------------->
   VAR_TO_FILE: 		>	List of current contributing	>
>				>		to ion pools		>
>------------------------------->--------------------------------------->
	V[b31_leak_only....]<{svr}	>	VAR name			>
	V[b31_axon....]<{svr}  	>	VAR name			>
>------------------------------->--------------------------------------->
	END:			>					>
>------------------------------->--------------------------------------->

END:

Loading data, please wait...