Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)

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Accession:116606
"Biophysical properties of neurons contributing to the ability of an animal to decide whether or not to respond were examined. B31/B32, two pairs of bilaterally symmetrical Aplysia neurons, are major participants in deciding to initiate a buccal motor program, the neural correlate of a consummatory feeding response. B31/B32 respond to an adequate stimulus after a delay, during which time additional stimuli influence the decision to respond. B31/B32 then respond with a ramp depolarization followed by a sustained soma depolarization and axon spiking that is the expression of a commitment to respond to food. Four currents contributing to decision making in B31/B32 were characterized, and their functional effects were determined, in current- and voltage-clamp experiments and with simulations. ... Hodgkin-Huxley kinetic analyses were performed on the outward currents. Simulations using equations from these analyses showed that IK-V and IK-A slow the ramp depolarization preceding the sustained depolarization. The three outward currents contribute to braking the B31/B32 depolarization and keeping the sustained depolarization at a constant voltage. The currents identified are sufficient to explain the properties of B31/B32 that play a role in generating the decision to feed."
Reference:
1 . Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ (2008) Currents contributing to decision making in neurons B31/B32 of Aplysia. J Neurophysiol 99:814-30 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Aplysia;
Cell Type(s): Aplysia B31/B32 neuron;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Action Selection/Decision Making;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K;
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hurwitzEtAl2008
with_all_currents_fast_stimulus
B_B63_K.a *
B_B63_K.b *
B_B63_Na.A *
B_B63_Na.B *
b31_axon.neu *
B31_axon_2_Soma.es *
b31_axon_K.vdg *
b31_axon_K2.vdg *
b31_axon_leak.vdg *
b31_axon_Na.vdg *
b31_leak_fixed.vdg *
b31_leak_only.neu *
b31_soma_K1.A *
b31_soma_K1.B *
b31_soma_K1.vdg *
b31_soma_K2.A *
b31_soma_K2.B *
b31_soma_K2.vdg *
b31_soma_K3.A *
b31_soma_K3.B *
b31_soma_K3.vdg *
b31_with_axon.ntw *
b31_with_axon.ous
b31_with_axon.ous.mnu
b31_with_axon.smu
b31_with_axon.smu.exec
b31_with_axon.smu.hmn
b31_with_axon.smu.ing
b31_with_axon.trt
b31_with_axon_vc.trt *
b31_with_axon_with_I_del.ous *
ousgrf.def *
simufiles.usd
                            
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>   modules name: smu          >>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>


>----------------------->------------------------------->
  LOGICAL_NAME:         >       Name of Network         >
>.......................>...............................>
        b31_with_axon   > The name of the network       >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TIMING:               > Timing information in seconds >
>.......................>...............................>
        0.0000000000    > What value to assign to the   >
                        > variable 'time' at time=0     >
>.......................>...............................>
        15.0000000000   > When to stop the simulation   >
>.......................>...............................>
        0.0000460000    > Step size (h)                 >
>----------------------->------------------------------->

>----------------------->------------------------------->
  ON_LINE_GRAPH:        >       On-line graph           >
>.......................>...............................>
        1               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  STORE_RESULTS:        >       Store results           >
>.......................>...............................>
        0               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  INT_METHOD:           >       Integration method      >
>.......................>...............................>
        1               > 1 for Euler method            >
                        > 2 for RK                      >
                        > 3 for RKQC                    >
>----------------------->------------------------------->

>----------------------->------------------------------->
  NETWORK:              > Structure of network          >
>.......................>...............................>
        b31_with_axon.ntw> the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  OUTPUT_SETUP:         > List of variables for output  >
>.......................>...............................>
        b31_with_axon.ous> the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TREATMENTS:           > External treatments           >
>.......................>...............................>
        b31_with_axon.trt> the name of the file          >
>----------------------->------------------------------->
  INT_&_FIRE:           >       Integration method      >
>.......................>...............................>
        0.0020000000    > Integrate And Fire step_size  >
>----------------------->------------------------------->

END

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