Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)

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Accession:116606
"Biophysical properties of neurons contributing to the ability of an animal to decide whether or not to respond were examined. B31/B32, two pairs of bilaterally symmetrical Aplysia neurons, are major participants in deciding to initiate a buccal motor program, the neural correlate of a consummatory feeding response. B31/B32 respond to an adequate stimulus after a delay, during which time additional stimuli influence the decision to respond. B31/B32 then respond with a ramp depolarization followed by a sustained soma depolarization and axon spiking that is the expression of a commitment to respond to food. Four currents contributing to decision making in B31/B32 were characterized, and their functional effects were determined, in current- and voltage-clamp experiments and with simulations. ... Hodgkin-Huxley kinetic analyses were performed on the outward currents. Simulations using equations from these analyses showed that IK-V and IK-A slow the ramp depolarization preceding the sustained depolarization. The three outward currents contribute to braking the B31/B32 depolarization and keeping the sustained depolarization at a constant voltage. The currents identified are sufficient to explain the properties of B31/B32 that play a role in generating the decision to feed."
Reference:
1 . Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ (2008) Currents contributing to decision making in neurons B31/B32 of Aplysia. J Neurophysiol 99:814-30 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Aplysia;
Cell Type(s): Aplysia B31/B32 neuron;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Action Selection/Decision Making;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K;
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hurwitzEtAl2008
with_all_currents_fast_stimulus
B_B63_K.a *
B_B63_K.b *
B_B63_Na.A *
B_B63_Na.B *
b31_axon.neu *
B31_axon_2_Soma.es *
b31_axon_K.vdg *
b31_axon_K2.vdg *
b31_axon_leak.vdg *
b31_axon_Na.vdg *
b31_leak_fixed.vdg *
b31_leak_only.neu *
b31_soma_K1.A *
b31_soma_K1.B *
b31_soma_K1.vdg *
b31_soma_K2.A *
b31_soma_K2.B *
b31_soma_K2.vdg *
b31_soma_K3.A *
b31_soma_K3.B *
b31_soma_K3.vdg *
b31_with_axon.ntw *
b31_with_axon.ous
b31_with_axon.ous.mnu
b31_with_axon.smu
b31_with_axon.smu.exec
b31_with_axon.smu.hmn
b31_with_axon.smu.ing
b31_with_axon.trt
b31_with_axon_vc.trt *
b31_with_axon_with_I_del.ous *
ousgrf.def *
simufiles.usd
                            
LOGICAL_NAME	b31_with_axon
TIMING: 0.0 15.0 4.6E-5
ON_LINE_GRAPH: 1
STORE_RESULTS: 0
INT_METHOD: 1
INT_&_FIRE: 0.0020
#NEUR	2
neur#=0	b31_axon

THRESHOLD	-10.0
SPIKDUR	0.0030
VMINIT	-60.0
CM	0.0030
MEM_AREA	1.0
is_TR=	0
#VDG	3
vdg#=0	leak
Ivd	5
#prm	2
0.0012	-60.0	
A	0
B	0
m	0
h	0
R	0
vdg#=1	Na
Ivd	1
#prm	3
4.0	3.0	50.0	
A	1
B	1
m	0
h	0
R	0
ACTIVATION=A	
A	2
#prm	1
-1.0	
ssA	1
#prm	3
-35.0	4.8	1.0	
tA	2
#prm	5
0.0015	4.5E-4	-32.7	1.85	1.0	
INACTIVATION=B	
B	2
#prm	1
-1.0	
ssB	1
#prm	3
-51.5	9.2	1.0	
tB	2
#prm	5
0.01	0.0024	-39.2	3.5	1.0	
vdg#=2	K
Ivd	1
#prm	3
20.0	4.0	-70.0	
A	1
B	1
m	0
h	0
R	0
ACTIVATION=A	
A	2
#prm	1
-1.0	
ssA	1
#prm	3
-26.4	8.8	1.0	
tA	3
#prm	8
0.027	0.00216	-24.0	11.7	1.0	-51.0	-11.2	1.0	
INACTIVATION=B	
B	2
#prm	1
-1.0	
ssB	2
#prm	4
0.15	-16.4	1.5	2.0	
tB	2
#prm	5
0.2	0.02	-24.0	8.3	1.0	
#ION	0
#SM	0
#I2C	0
#gbi	0
#gbs	0
#tbi	0
#tbs	0
#sbi	0
#sbs	0
#LDG	0
#CC	0
#MOB	0
#TRP	0
neur#=1	b31_leak_only

THRESHOLD	0.0
SPIKDUR	0.0030
VMINIT	-60.0
CM	0.011
MEM_AREA	1.0
is_TR=	0
#VDG	4
vdg#=0	b31_del_rec
Ivd	1
#prm	3
15.0	1.0	-70.0	
A	1
B	1
m	0
h	0
R	0
ACTIVATION=A	
A	2
#prm	1
-1.0	
ssA	1
#prm	3
6.0	14.0	1.0	
tA	3
#prm	8
0.014	0.0030	20.0	7.0	1.0	-15.0	-6.0	1.0	
INACTIVATION=B	
B	2
#prm	1
-1.0	
ssB	1
#prm	3
-31.0	7.0	1.0	
tB	3
#prm	8
0.875	0.11	-15.0	6.0	1.0	-73.0	-9.0	1.0	
vdg#=1	Leak
Ivd	5
#prm	2
0.37	-60.0	
A	0
B	0
m	0
h	0
R	0
vdg#=2	b31_A_current
Ivd	1
#prm	3
9.5	1.0	-85.0	
A	1
B	1
m	0
h	0
R	0
ACTIVATION=A	
A	2
#prm	1
-1.0	
ssA	1
#prm	3
-14.0	20.0	3.0	
tA	3
#prm	8
0.02	2.75E-4	-88.0	30.0	1.0	-50.0	-5.0	1.0	
INACTIVATION=B	
B	2
#prm	1
-1.0	
ssB	1
#prm	3
-30.0	11.0	1.0	
tB	3
#prm	8
0.33	0.0080	-56.0	-16.0	1.0	-80.0	70.0	1.0	
vdg#=3	maintained
Ivd	1
#prm	3
5.0	1.0	-35.0	
A	1
B	1
m	0
h	0
R	0
ACTIVATION=A	
A	2
#prm	1
-1.0	
ssA	1
#prm	3
19.0	11.0	1.0	
tA	3
#prm	8
0.014	0.0030	20.0	7.0	1.0	-15.0	-6.0	1.0	
INACTIVATION=B	
B	1
#prm	0

ssB	1
#prm	3
1000.0	7.0	1.0	
tB	0
#prm	0

#ION	0
#SM	0
#I2C	0
#gbi	0
#gbs	0
#tbi	0
#tbs	0
#sbi	0
#sbs	0
#LDG	0
#CC	0
#MOB	0
#TRP	0

#CELL	0

#ESYN	1
esyn#=0	1	b31_leak_only	0	b31_axon
Ies	1
#prm	2
0.4	0.075	
R1=	0
R2=	0
#CSYN	0
#MSYN	0
#WEIGHT	0

#RSYN	0
#CINJ	35
	0	b31_axon	0.0	0.0	0.25
	1	b31_leak_only	0.5	0.9	0.5
	2	b31_leak_only	0.9	1.2	1.0
	3	b31_leak_only	1.2	1.6	2.0
	4	b31_leak_only	1.6	1.9	3.0
	5	b31_leak_only	1.9	2.1	4.0
	6	b31_leak_only	2.1	2.4	5.0
	7	b31_leak_only	2.4	2.65	6.0
	8	b31_leak_only	2.65	2.8	7.0
	9	b31_leak_only	2.8	2.95	8.0
	10	b31_leak_only	2.95	3.1	12.5
	11	b31_leak_only	3.1	3.25	17.0
	12	b31_leak_only	3.25	3.35	19.0
	13	b31_leak_only	3.35	3.45	20.5
	14	b31_leak_only	3.45	3.55	22.0
	15	b31_leak_only	3.55	3.65	24.5
	16	b31_leak_only	3.65	3.7	27.0
	17	b31_leak_only	3.7	3.75	30.0
	18	b31_leak_only	3.75	3.8	40.0
	19	b31_leak_only	3.8	4.0	52.0
	20	b31_leak_only	4.0	4.5	65.0
	21	b31_leak_only	4.5	5.0	70.0
	22	b31_leak_only	5.0	5.25	67.0
	23	b31_leak_only	5.25	5.5	65.0
	24	b31_leak_only	5.5	5.75	63.0
	25	b31_leak_only	5.75	6.0	61.0
	26	b31_leak_only	6.0	6.25	58.75
	27	b31_leak_only	6.25	6.5	58.0
	28	b31_leak_only	6.5	7.0	57.0
	29	b31_leak_only	7.0	7.5	57.5
	30	b31_leak_only	7.5	8.0	56.0
	31	b31_leak_only	8.0	8.5	55.75
	32	b31_leak_only	8.5	9.0	56.2
	33	b31_leak_only	9.0	9.5	56.5
	34	b31_leak_only	9.5	10.0	56.0
#MINJ	0
#VCLMP	0
#ICLMP	0
#LIGHT	0

Ousfile_PATH  C:\Temp\hurwitzEtAl2008\hurwitzEtAl2008\with_all_currents_fast_stimulus\b31_with_axon.ous
#GRAPH_CHNL	2
gain=	1
nvar=	1
name=	time<{ivr}
vartype=	3
n_tic=	12
min=	0.0
max=	12.0
color=	green
gain=	1
nvar=	1
name=	time<{ivr}
vartype=	3
n_tic=	12
min=	0.0
max=	12.0
color=	blue
#GRAPH_VAR	2
chn_id=	0
name=	V[b31_leak_only....]<{svr}
name2=	NULL
vartype=	1
vartype2=	-1
n_tic=	13
min=	-65.0
max=	0.0
color=	green
chn_id=	1
name=	V[b31_axon....]<{svr}
name2=	NULL
vartype=	1
vartype2=	-1
n_tic=	13
min=	-65.0
max=	0.0
color=	blue
#VAR2FILE		2
name=	V[b31_leak_only....]<{svr}
vartype=	1
name=	V[b31_axon....]<{svr}
vartype=	1


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