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Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
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Model Information
Model File
Citations
Accession:
116606
"Biophysical properties of neurons contributing to the ability of an animal to decide whether or not to respond were examined. B31/B32, two pairs of bilaterally symmetrical Aplysia neurons, are major participants in deciding to initiate a buccal motor program, the neural correlate of a consummatory feeding response. B31/B32 respond to an adequate stimulus after a delay, during which time additional stimuli influence the decision to respond. B31/B32 then respond with a ramp depolarization followed by a sustained soma depolarization and axon spiking that is the expression of a commitment to respond to food. Four currents contributing to decision making in B31/B32 were characterized, and their functional effects were determined, in current- and voltage-clamp experiments and with simulations. ... Hodgkin-Huxley kinetic analyses were performed on the outward currents. Simulations using equations from these analyses showed that IK-V and IK-A slow the ramp depolarization preceding the sustained depolarization. The three outward currents contribute to braking the B31/B32 depolarization and keeping the sustained depolarization at a constant voltage. The currents identified are sufficient to explain the properties of B31/B32 that play a role in generating the decision to feed."
Reference:
1 .
Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ (2008) Currents contributing to decision making in neurons B31/B32 of Aplysia.
J Neurophysiol
99
:814-30
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Aplysia;
Cell Type(s):
Aplysia B31/B32 neuron;
Channel(s):
I Na,t;
I A;
I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
SNNAP;
Model Concept(s):
Action Selection/Decision Making;
Implementer(s):
Search NeuronDB
for information about:
I Na,t
;
I A
;
I K
;
/
hurwitzEtAl2008
with_all_currents_slow_stimulus
B_B63_K.a
*
Other models using B_B63_K.a:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
B_B63_K.b
*
Other models using B_B63_K.b:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
B_B63_Na.A
*
Other models using B_B63_Na.A:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
B_B63_Na.B
*
Other models using B_B63_Na.B:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_axon.neu
*
Other models using b31_axon.neu:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
B31_axon_2_Soma.es
*
Other models using B31_axon_2_Soma.es:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_axon_K.vdg
*
Other models using b31_axon_K.vdg:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_axon_K2.vdg
*
Other models using b31_axon_K2.vdg:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_axon_leak.vdg
*
Other models using b31_axon_leak.vdg:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_axon_Na.vdg
*
Other models using b31_axon_Na.vdg:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_leak_fixed.vdg
*
Other models using b31_leak_fixed.vdg:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_leak_only.neu
*
Other models using b31_leak_only.neu:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_soma_K1.A
*
Other models using b31_soma_K1.A:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_soma_K1.B
*
Other models using b31_soma_K1.B:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_soma_K1.vdg
*
Other models using b31_soma_K1.vdg:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_soma_K2.A
*
Other models using b31_soma_K2.A:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_soma_K2.B
*
Other models using b31_soma_K2.B:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_soma_K2.vdg
*
Other models using b31_soma_K2.vdg:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_soma_K3.A
*
Other models using b31_soma_K3.A:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_soma_K3.B
*
Other models using b31_soma_K3.B:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_soma_K3.vdg
*
Other models using b31_soma_K3.vdg:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_with_axon.ntw
*
Other models using b31_with_axon.ntw:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_with_axon.ous
b31_with_axon.ous.mnu
b31_with_axon.smu
b31_with_axon.smu.exec
b31_with_axon.smu.hmn
b31_with_axon.smu.ing
b31_with_axon.trt
b31_with_axon_vc.trt
*
Other models using b31_with_axon_vc.trt:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
b31_with_axon_with_I_del.ous
*
Other models using b31_with_axon_with_I_del.ous:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
Copy of b31_with_axon.trt
ousgrf.def
*
Other models using ousgrf.def:
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
Effects of Acetyl-L-carnitine on neural transmission (Lombardo et al 2004)
Effects of Acetyl-L-carnitine on neural transmission (Lombardo et al 2004)
Touch Sensory Cells (T Cells) of the Leech (Cataldo et al. 2004) (Scuri et al. 2007)
Touch Sensory Cells (T Cells) of the Leech (Cataldo et al. 2004) (Scuri et al. 2007)
Touch Sensory Cells (T Cells) of the Leech (Cataldo et al. 2004) (Scuri et al. 2007)
simufiles.usd
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