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Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)
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Accession:
116835
A detailed multicompartmental model was used to study neuronal electroresponsiveness of cerebellar granule cells in rats. Here we show that, in cerebellar granule cells, Na+ channels are enriched in the axon, especially in the hillock, but almost absent from soma and dendrites. Numerical simulations indicated that granule cells have a compact electrotonic structure allowing EPSPs to diffuse with little attenuation from dendrites to axon. The spike arose almost simultaneously along the whole axonal ascending branch and invaded the hillock, whose activation promoted spike back-propagation with marginal delay (<200 micros) and attenuation (<20 mV) into the somato-dendritic compartment. For details check the cited article.
Reference:
1 .
Diwakar S, Magistretti J, Goldfarb M, Naldi G, D'Angelo E (2009) Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells.
J Neurophysiol
101
:519-32
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cerebellum;
Cell Type(s):
Cerebellum interneuron granule GLU cell;
Channel(s):
I A;
I M;
I h;
I K,Ca;
I Sodium;
I Calcium;
I Potassium;
I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Active Dendrites;
Detailed Neuronal Models;
Axonal Action Potentials;
Action Potentials;
Intrinsic plasticity;
Implementer(s):
Diwakar, Shyam [shyam at amrita.edu];
Search NeuronDB
for information about:
Cerebellum interneuron granule GLU cell
;
I A
;
I M
;
I h
;
I K,Ca
;
I Sodium
;
I Calcium
;
I Potassium
;
I A, slow
;
/
GrC
fig10
readme.html
AmpaCOD.mod
*
Other models using AmpaCOD.mod:
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_CA.mod
*
Other models using GRC_CA.mod:
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_CALC.mod
*
Other models using GRC_CALC.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_GABA.mod
*
Other models using GRC_GABA.mod:
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KA.mod
*
Other models using GRC_KA.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KCA.mod
*
Other models using GRC_KCA.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KIR.mod
*
Other models using GRC_KIR.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KM.mod
*
Other models using GRC_KM.mod:
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Cerebellar granule cell (Masoli et al 2020)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_KV.mod
*
Other models using GRC_KV.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_LKG1.mod
*
Other models using GRC_LKG1.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_LKG2.mod
*
Other models using GRC_LKG2.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
GRC_NA.mod
*
Other models using GRC_NA.mod:
Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
NmdaS.mod
*
Other models using NmdaS.mod:
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
Pregen.mod
*
Other models using Pregen.mod:
Cerebellum granule cell FHF (Dover et al. 2016)
Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)
ComPanel.hoc
Grc_Cell.hoc
mosinit.hoc
Parametri.hoc
screenshot.jpg
simple.ses
Start.hoc
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