Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)
Download zip file
Help downloading and running models
Versions on GitHub
A detailed multicompartmental model was used to study neuronal electroresponsiveness of cerebellar granule cells in rats. Here we show that, in cerebellar granule cells, Na+ channels are enriched in the axon, especially in the hillock, but almost absent from soma and dendrites. Numerical simulations indicated that granule cells have a compact electrotonic structure allowing EPSPs to diffuse with little attenuation from dendrites to axon. The spike arose almost simultaneously along the whole axonal ascending branch and invaded the hillock, whose activation promoted spike back-propagation with marginal delay (<200 micros) and attenuation (<20 mV) into the somato-dendritic compartment. For details check the cited article.
Diwakar S, Magistretti J, Goldfarb M, Naldi G, D'Angelo E (2009) Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells.
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
Cerebellum interneuron granule GLU cell;
I A, slow;
Action Potential Initiation;
Detailed Neuronal Models;
Axonal Action Potentials;
Diwakar, Shyam [shyam at amrita.edu];
for information about:
Cerebellum interneuron granule GLU cell
I A, slow
File not selected
<- Select file from this column.
Load Model View
Loading data, please wait...