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Response properties of neocort. neurons to temporally modulated noisy inputs (Koendgen et al. 2008)

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Accession:118631
Neocortical neurons are classified by current–frequency relationship. This is a static description and it may be inadequate to interpret neuronal responses to time-varying stimuli. Theoretical studies (Brunel et al., 2001; Fourcaud-Trocmé et al. 2003; Fourcaud-Trocmé and Brunel 2005; Naundorf et al. 2005) suggested that single-cell dynamical response properties are necessary to interpret ensemble responses to fast input transients. Further, it was shown that input-noise linearizes and boosts the response bandwidth, and that the interplay between the barrage of noisy synaptic currents and the spike-initiation mechanisms determine the dynamical properties of the firing rate. In order to allow a reader to explore such simulations, we prepared a simple NEURON implementation of the experiments performed in Köndgen et al., 2008 (see also Fourcaud-Trocmé al. 2003; Fourcaud-Trocmé and Brunel 2005). In addition, we provide sample MATLAB routines for exploring the sandwich model proposed in Köndgen et al., 2008, employing a simple frequdency-domain filtering. The simulations and the MATLAB routines are based on the linear response properties of layer 5 pyramidal cells estimated by injecting a superposition of a small-amplitude sinusoidal wave and a background noise, as in Köndgen et al., 2008.
References:
1 . Koendgen H, Geisler C, Wang XJ, Fusi S, Luescher HR, Giugliano M (2004) The dynamical response of single cells to noisy time-varying currents Soc Neurosci Abstr :640
2 . Köndgen H, Geisler C, Fusi S, Wang XJ, Lüscher HR, Giugliano M (2008) The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro. Cereb Cortex 18:2086-97 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Axon;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Abstract Wang-Buzsaki neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Parameter Fitting; Methods; Rate-coding model neurons;
Implementer(s): Giugliano, Michele [mgiugliano at gmail.com]; Delattre, Vincent;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I Na,t; I K; 
//
// InjectSinusoid()
//
// Sinusoidal, noisy currents injection procedure with a modulation on S
// This defines a user-function InjectSinuNoisy(), taking 5 input parameters..
// 
// 
// M. Giugliano & V. Delattre, Brain Mind Institute, EPFL, Feb 2008
//

objref fl

proc InjectSinuNoisy() {

m           = $1        // DC offset of the overall current
s           = $2        // square root of the steady-state variance of the (noisy) stimulus component
tau         = $3        // steady-state correlation time-length of the (noisy) stimulus component
amp         = $4        // amplitude of the (sinusoidal) stimulus component
freq        = $5        // steady-state correlation time-length of the (noisy) stimulus component

fl          = new Isinunoisy2(0.5)     // Sinusoidal + Noisy current-clamp stimulation
fl.m        = m
fl.s        = s
fl.tau      = tau
fl.amp      = amp
fl.freq     = freq

} // end InjectSinuNoisy()

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