"Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects
on cardiac voltage-gated Na(+) channels. However, it remains unknown whether it has
any effects on K(+) currents. The effects of ACO on ion currents in differentiated
clonal cardiac (H9c2) cells and in cultured neonatal rat ventricular myocytes were
investigated in this study. ..." The rat action potential in this simulation was played back into the cell for experiments reported in this paper.
Reference:
1 .
Wang YJ, Chen BS, Lin MW, Lin AA, Peng H, Sung RJ, Wu SN (2008) Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes. Toxicol Sci 106:454-63 [PubMed]
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