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A model of beta-adrenergic modulation of IKs in the guinea-pig ventricle (Severi et al. 2009)
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Detailed understanding of IKs gating complexity may provide clues on the mechanisms of cardiac repolarization instability and the resulting arrhythmias. We developed and tested a kinetic Markov model to interpret physiologically relevant IKs properties, including pause-dependency and modulation by beta-adrenergic receptors (beta-AR). The model was developed from the Silva & Rudy formulation. Parameters were optimized on control and ISO experimental data, respectively.
Severi S, Corsi C, Rocchetti M, Zaza A (2009) Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis.
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Cardiac ventricular cell;
Ion Channel Kinetics;
Severi, Stefano [stefano.severi at unibo.it];
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