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Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009)
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"Inward rectifying potassium (KIR) currents in medium spiny (MS) neurons of nucleus accumbens inactivate significantly in ~40% of the neurons but not in the rest, which may lead to differences in input processing by these two groups. Using a 189-compartment computational model of the MS neuron, we investigate the influence of this property using injected current as well as spatiotemporally distributed synaptic inputs. Our study demonstrates that KIR current inactivation facilitates depolarization, firing frequency and firing onset in these neurons. ..."
Steephen JE, Manchanda R (2009) Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents.
J Comput Neurosci
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Neuron or other electrically excitable cell;
Nucleus accumbens spiny projection neuron;
I L high threshold;
I T low threshold;
I A, slow;
Action Potential Initiation;
Ion Channel Kinetics;
Steephen, John Eric [johneric at duk.ac.in];
for information about:
I L high threshold
I T low threshold
I A, slow
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