Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009)

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Accession:121060
"Inward rectifying potassium (KIR) currents in medium spiny (MS) neurons of nucleus accumbens inactivate significantly in ~40% of the neurons but not in the rest, which may lead to differences in input processing by these two groups. Using a 189-compartment computational model of the MS neuron, we investigate the influence of this property using injected current as well as spatiotemporally distributed synaptic inputs. Our study demonstrates that KIR current inactivation facilitates depolarization, firing frequency and firing onset in these neurons. ..."
Reference:
1 . Steephen JE, Manchanda R (2009) Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents. J Comput Neurosci 27:453-70 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Nucleus accumbens spiny projection neuron;
Channel(s): I Na,p; I L high threshold; I T low threshold; I p,q; I A; I h; I K,Ca; I CAN; I A, slow; I Krp; I R;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s): Cav1.3 CACNA1D; Cav1.2 CACNA1C; IRK;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Action Potentials; Synaptic Integration; Delay;
Implementer(s): Steephen, John Eric [johneric at duk.ac.in];
Search NeuronDB for information about:  AMPA; NMDA; Gaba; I Na,p; I L high threshold; I T low threshold; I p,q; I A; I h; I K,Ca; I CAN; I A, slow; I Krp; I R; 
/* Execute main.hoc to run the program. The program implements the model described in Steephen & Manchanda, 2009.
 * 
 * Steephen, J. E., & Manchanda, R. (2009). Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents. J Comput Neurosci, 
 * doi:10.1007/s10827-009-0161-7
 */
 
//KIR
objref vecmtau_KIR, vecv_KIR
vecmtau_KIR = new Vector()
vecv_KIR = new Vector()
vecv_KIR.indgen(-120, 0, 10)
vecmtau_KIR.append(7.465, 7.465, 7.465, 8, 9.435, 10.755, 12.12, 13.795, 15.385, 14.285, 11.765, 8.89, 8) // At 35 deg C
table_tabmtau_KIR(&vecmtau_KIR.x[0], vecv_KIR.size, &vecv_KIR.x[0]) 

//inKIR
objref vecv_inKIR, vechinf_inKIR, vechtau_inKIR, vecv_tau_inKIR
vecv_tau_inKIR = new Vector()
vechtau_inKIR= new Vector()
vecv_tau_inKIR.append(-120,-90, -50)
vechtau_inKIR.append(7.767, 15, 25.333) // At 35 deg C
table_tabhtau_inKIR(&vechtau_inKIR.x[0],vecv_tau_inKIR.size, &vecv_tau_inKIR.x[0])

vecv_inKIR = new Vector()
vechinf_inKIR = new Vector()
vecv_inKIR.append(-120,-90, -50)
vechinf_inKIR.append(0, 0.13, 1)
table_tabhinf_inKIR(&vechinf_inKIR.x[0], vecv_inKIR.size, &vecv_inKIR.x[0])
table_tabmtau_inKIR(&vecmtau_KIR.x[0], vecv_KIR.size, &vecv_KIR.x[0]) 

//KRP
objref vecv_KRP, vecmtau_KRP, vechtau_KRP
vecv_KRP = new Vector()
vecv_KRP.indgen(-100, 50, 5)

vecmtau_KRP = new Vector()
vecmtau_KRP.append(13.33, 15, 16.27, 18.33, 21.47, 25, 27.97, 30, 31.17, 31.67, 31.8, 32.33, 33.07, 31.67, 26.57, 20, 14.83, 11.67, 9.77, 8.33, 6.67, 5, 3.87, 3.33, 3.2, 3.33, 3.5, 3.33, 2.67, 1.67, 1.67)
table_tabmtau_KRP(&vecmtau_KRP.x[0], vecv_KRP.size, &vecv_KRP.x[0])

vechtau_KRP = new Vector()
vechtau_KRP.append(2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2333.33,2247.5,2000,1580.07,1166.67,927.77,833.33,778.77,733.33,694.5,666.67,666.67)
table_tabhtau_KRP(&vechtau_KRP.x[0], vecv_KRP.size, &vecv_KRP.x[0])

objref vecv_NaF, vecmtau_NaF, vechtau_NaF
vecv_NaF = new Vector()
vecv_NaF.indgen(-90, 30, 10)

vecmtau_NaF = new Vector()
vecmtau_NaF.append(0.02,0.023,0.03,0.037,0.043,0.067,0.107,0.053,0.05,0.04,0.027,0.02,0.02)
table_tabmtau_NaF(&vecmtau_NaF.x[0], vecv_NaF.size, &vecv_NaF.x[0])

vechtau_NaF = new Vector()
vechtau_NaF.append(0.433,0.433,0.433,0.433,0.433,0.433,0.433,0.283,0.167,0.15,0.107,0.1,0.093)
table_tabhtau_NaF(&vechtau_NaF.x[0], vecv_NaF.size, &vecv_NaF.x[0])

//CaT
objref vecv_CaT, vecmtau_CaT, vechtau_CaT
vecv_CaT = new Vector()
vecv_CaT.indgen(-65, 10, 5)

vecmtau_CaT = new Vector()
vecmtau_CaT.append(6.73,6.73,4.37,2.9,2.27,1.87,1.47,1.27,1.2,1.1,1.2,1.2,1.1,1.1,1.1,1.1)
table_tabmtau_CaT(&vecmtau_CaT.x[0], vecv_CaT.size, &vecv_CaT.x[0])

vechtau_CaT = new Vector()
vechtau_CaT.append(127.33,69.33,54,43,39.67,35.67,35.67,35.67,36,36.33,36.33,36.67,36.67,36.67,36.67,36.67)
table_tabhtau_CaT(&vechtau_CaT.x[0], vecv_CaT.size, &vecv_CaT.x[0])

//CaR
objref vecv_CaR, vechtau_CaR
vecv_CaR = new Vector()
vecv_CaR.indgen(-30, 10, 10)

vechtau_CaR = new Vector()
vechtau_CaR.append(33.33,21.67,11.67,10.00,6.67)
table_tabhtau_CaR(&vechtau_CaR.x[0], vecv_CaR.size, &vecv_CaR.x[0])

//NaP
objref vecv_NaP, vechtau_NaP
vecv_NaP = new Vector()
vecv_NaP.indgen(-100, 10, 10)

vechtau_NaP = new Vector()
vechtau_NaP.append(1500, 1583.33, 1733.33, 2033.33, 2100, 1666.67, 1416.67, 1166.67, 1000, 900, 833.33, 700)
table_tabhtau_NaP(&vechtau_NaP.x[0], vecv_NaP.size, &vecv_NaP.x[0])

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