ModelDB: CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)

CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)

Download zip file
Help downloading and running models

Model Information
Model File
Citations
Model Views
Simulation Platform

Accession:125152

A model of a CA1 pyramidal neuron containing a biophysically realistic morphology and 15 distributed voltage and Ca2+-dependent conductances. Repetitive firing is modulated by maximal conductance and the voltage dependence of the persistent Na+ current (INaP).
Reference:
1 . Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010) Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J Neurosci 30:8489-501 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,p; I Na,t; I p,q; I A; I K,leak; I M; I K,Ca; I CAN; I Calcium; ATP-senstive potassium current;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Detailed Neuronal Models; Epilepsy;
Implementer(s):	Horstmann, Marie-Therese [mhorstma at uni-bonn.de];