Levetiracetam (LEV) is an S-enantiomer pyrrolidone derivative with established antiepileptic
efficacy in generalized epilepsy and partial epilepsy. However, its effects on ion currents
and membrane potential remain largely unclear. In this study, we investigated the effect of
LEV on differentiated NG108-15 neurons.
...
Simulation studies in a modified
Hodgkin-Huxley neuron and network unraveled that the reduction of slowly inactivating IK(DR) resulted
in membrane depolarization accompanied by termination of the firing of action potentials in a
stochastic manner. Therefore, the inhibitory effects on slowly inactivating IK(DR) (Kv3.1-encoded
current) may constitute one of the underlying mechanisms through which LEV affects neuronal activity
in vivo.
Reference:
1 .
Huang CW, Tsai JJ, Huang CC, Wu SN (2009) Experimental and simulation studies on the mechanisms of levetiracetam-mediated inhibition of delayed-rectifier potassium current (KV3.1): contribution to the firing of action potentials. J Physiol Pharmacol 60:37-47 [PubMed]
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