Computer model of clonazepam's effect in thalamic slice (Lytton 1997)

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Accession:12631
Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Reference:
1 . Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice. Neuroreport 8:3339-43 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell;
Channel(s): I Na,t; I T low threshold; I K; I CAN;
Gap Junctions:
Receptor(s): GabaA; Gaba;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting; Therapeutics; Epilepsy; Calcium dynamics;
Implementer(s): Lytton, William [bill.lytton at downstate.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; GabaA; Gaba; I Na,t; I T low threshold; I K; I CAN; Gaba;
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lytton97b
README
AMPA.mod
calciumpump_destexhe.mod *
GABAA.mod
GABAB1.mod
GABALOW.mod
HH_traub.mod *
IAHP_destexhe.mod
ICAN_destexhe.mod
ICAN_voltdep.mod
Ih_old.mod *
IT_wang.mod
IT2_huguenard.mod
NMDA.mod
passiv.mod *
pregen.mod *
presyn.mod *
pulse.mod
rand.mod
bg.inc *
boxes.hoc
ctl.dat
ctlnew.dat
czp.dat
czpnew.dat
declist.hoc *
decvec.hoc *
default.hoc *
disp.hoc
Fig3.gif
Fig4.gif
geom.hoc
grvec.hoc
init.hoc
labels.hoc
local.hoc
mod_func.c
mosinit.hoc
network.hoc
neurrep8
nrnoc.hoc
params.hoc
presyn.inc *
queue.inc *
run.hoc
show.hoc
simctrl.hoc *
sns.inc *
snsarr.inc
snscode.hoc
snsgr.hoc
snshead.inc *
synq.inc *
xtmp
                            
#include <stdio.h>
modl_reg(){
	fprintf(stderr, "Additional mechanisms from files\n");

fprintf(stderr," AMPA.mod");
fprintf(stderr," GABAA.mod");
fprintf(stderr," GABAB1.mod");
fprintf(stderr," GABALOW.mod");
fprintf(stderr," HH_traub.mod");
fprintf(stderr," IAHP_destexhe.mod");
fprintf(stderr," ICAN_destexhe.mod");
fprintf(stderr," ICAN_voltdep.mod");
fprintf(stderr," IT2_huguenard.mod");
fprintf(stderr," IT_wang.mod");
fprintf(stderr," Ih_old.mod");
fprintf(stderr," NMDA.mod");
fprintf(stderr," calciumpump_destexhe.mod");
fprintf(stderr," passiv.mod");
fprintf(stderr," pregen.mod");
fprintf(stderr," presyn.mod");
fprintf(stderr," pulse.mod");
fprintf(stderr," rand.mod");
fprintf(stderr, "\n");
_AMPA_reg();
_GABAA_reg();
_GABAB1_reg();
_GABALOW_reg();
_HH_traub_reg();
_IAHP_destexhe_reg();
_ICAN_destexhe_reg();
_ICAN_voltdep_reg();
_IT2_huguenard_reg();
_IT_wang_reg();
_Ih_old_reg();
_NMDA_reg();
_calciumpump_destexhe_reg();
_passiv_reg();
_pregen_reg();
_presyn_reg();
_pulse_reg();
_rand_reg();
}

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