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NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
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Accession:
126640
Cannabinoid withdrawal produces a hypofunction of dopaminergic neurons targeting medium spiny neurons (MSN) of the forebrain. Administration of a CB1 receptor antagonist to control rats provoked structural abnormalities, reminiscent of those observed in withdrawal conditions and support the regulatory role of cannabinoids in neurogenesis, axonal growth and synaptogenesis. Experimental observations were incorporated into a realistic computational model which predicts a strong reduction in the excitability of morphologically-altered MSN, yielding a significant reduction in action potential output. These paper provided direct morphological evidence for functional abnormalities associated with cannabinoid dependence at the level of dopaminergic neurons and their post synaptic counterpart, supporting a hypodopaminergic state as a distinctive feature of the “addicted brain”.
Reference:
1 .
Spiga S, Lintas A, Migliore M, Diana M (2010) Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence.
Addict Biol
15
:266-76
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Dendrite;
Brain Region(s)/Organism:
Basal ganglia;
Cell Type(s):
Nucleus accumbens spiny projection neuron;
Channel(s):
I Na,t;
I A;
I Potassium;
I A, slow;
I Krp;
Gap Junctions:
Receptor(s):
AMPA;
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Activity Patterns;
Active Dendrites;
Detailed Neuronal Models;
Action Potentials;
Synaptic Integration;
Addiction;
Implementer(s):
Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB
for information about:
AMPA
;
I Na,t
;
I A
;
I Potassium
;
I A, slow
;
I Krp
;
Glutamate
;
Download the displayed file
/
withdrawal
tau_tables
CVS
tauh_car.txt
*
Other models using tauh_car.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
tauh_cat.txt
*
Other models using tauh_cat.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
tauh_kas.txt
*
Other models using tauh_kas.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
tauh_krp.txt
*
Other models using tauh_krp.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
tauh_naf.txt
*
Other models using tauh_naf.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
tauh_nap.txt
*
Other models using tauh_nap.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
taum_cat.txt
*
Other models using taum_cat.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
taum_kaf.txt
*
Other models using taum_kaf.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
taum_kas.txt
*
Other models using taum_kas.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
taum_kir.txt
*
Other models using taum_kir.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
taum_krp.txt
*
Other models using taum_krp.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
taum_naf.txt
*
Other models using taum_naf.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
vtau_car.txt
*
Other models using vtau_car.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
vtau_cat.txt
*
Other models using vtau_cat.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
vtau_kaf.txt
*
Other models using vtau_kaf.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
vtau_kas.txt
*
Other models using vtau_kas.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
vtau_kir.txt
*
Other models using vtau_kir.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
vtau_krp.txt
*
Other models using vtau_krp.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
vtau_naf.txt
*
Other models using vtau_naf.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
vtau_nap.txt
*
Other models using vtau_nap.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
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