ModelDB: Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)

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Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)

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Accession:127021

Patch-clamp in cerebellar slices and computer modeling show that ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase. In particular, voltage-clamp recordings of Na+/K+ ATPase currents indicated that ethanol partially inhibits this pump and this effect could be mimicked by low concentrations of the Na+/K+ ATPase blocker ouabain. The partial inhibition of Na+/K+ ATPase in a computer model of the Golgi cell reproduced these experimental findings that established a novel mechanism of action of ethanol on neural excitability.
Reference:
1 . Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela CF (2010) Alcohol excites cerebellar Golgi cells by inhibiting the Na+/K+ ATPase. Neuropsychopharmacology 35:1984-96 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:	Cerebellum;
Cell Type(s):	Cerebellum golgi cell;
Channel(s):	Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):	HCN1;
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Detailed Neuronal Models; Markov-type model; Alcohol Use Disorder;
Implementer(s):	Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];