Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)
Download zip file
Help downloading and running models
Versions on GitHub
Patch-clamp in cerebellar slices and computer modeling show that ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase. In particular, voltage-clamp recordings of Na+/K+ ATPase currents indicated that ethanol partially inhibits this pump and this effect could be mimicked by low concentrations of the Na+/K+ ATPase blocker ouabain. The partial inhibition of Na+/K+ ATPase in a computer model of the Golgi cell reproduced these experimental findings that established a novel mechanism of action of ethanol on neural excitability.
Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela CF (2010) Alcohol excites cerebellar Golgi cells by inhibiting the Na+/K+ ATPase.
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
Cerebellum golgi cell;
Detailed Neuronal Models;
Alcohol Use Disorder;
Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
for information about:
File not selected
<- Select file from this column.
Load Model View
Loading data, please wait...