ModelDB: Medial reticular formation of the brainstem: anatomy and dynamics (Humphries et al. 2006, 2007)

Medial reticular formation of the brainstem: anatomy and dynamics (Humphries et al. 2006, 2007)

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Accession:128816

A set of models to study the medial reticular formation (mRF) of the brainstem. We developed a collection of algorithms to derive the adult-state wiring of the model: one set a stochastic model; the other set mimicking the developmental process. We found that the anatomical models had small-world properties, irrespective of the choice of algorithm; and that the cluster-like organisation of the mRF may have arisen to minimise wiring costs. (The model code includes options to be run as dynamic models; papers examining these dynamics are included in the .zip file).
References:
1 . Humphries MD, Gurney K, Prescott TJ (2006) The brainstem reticular formation is a small-world, not scale-free, network. Proc Biol Sci 273:503-11 [PubMed]
2 . Humphries MD, Gurney K, Prescott TJ (2007) Is there a brainstem substrate for action selection? Philos Trans R Soc Lond B Biol Sci 362:1627-39 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	MATLAB;
Model Concept(s):	Activity Patterns; Action Selection/Decision Making; Connectivity matrix; Development; Sensory processing;
Implementer(s):	Humphries, Mark D [m.d.humphries at shef.ac.uk];