Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)

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Accession:135787
" ... Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca21- dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals."
References:
1 . Shu Y, Duque A, Yu Y, Haider B, McCormick DA (2007) Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. J Neurophysiol 97:746-60 [PubMed]
2 . Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 441:761-5 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I_AHP; I_KD;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models; Action Potentials; Synaptic Integration;
Implementer(s):
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I_AHP; I_KD;
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ShuEtAl20062007
readme.txt
ampa5.mod *
ca.mod *
cad.mod
caL3d.mod *
capump.mod
gabaa5.mod *
Gfluct.mod *
ia.mod *
iahp.mod *
iahp2.mod *
ih.mod
im.mod *
kca.mod *
km.mod *
kv.mod *
na.mod *
NMDA_Mg.mod *
nmda5.mod *
release.mod *
2006_Nature.pdf
2006_Nature_supp.pdf
best_full_axon_decay.hoc
best_full_axon_spike_init.hoc
decay_constant.gif
for_decay.m
for_initiation.m
j4a.hoc *
j4a_removedendrite.hoc
j4a_removedendrite1.hoc
j7.hoc *
j8.hoc *
j8_removedendrite.hoc
lcAS3.hoc *
mosinit.hoc
spike_initiation.gif
                            
/*----------------------------------------------------------------
%W%  %G%
j4.txt  translated Mon Nov  1 16:56:20 1993 by ntscable 2.0
source file syntax: Douglas 3D
output file syntax: CABLE
soma: diameter = 25 um length = 35 um area = 2747.9 um2
11 primary neurites
87 branches totaling 17667.6 um in length, 52996.2 um2 in area
3383 tree points translated to 164 segments (1 requested)
Neurites divided into segments of equal dx between adjacent digitized
branch points.
Segment length constrained to be < 17667.6 um.
----------------------------------------------------------------*/
					/* create sections */
create    soma,\
          dend0,\
          dend1,\
          dend2,\
          dend3
/*----------------------------------------------------------------*/
proc geometry() { local i, j

						/* soma geometry */
    soma {
        nseg = 1
	diam = 25
	L = 35
    }

					/* connect primary neurites */
    soma connect dend0 (0), 0
    soma connect dend1 (0), 1
    dend1 connect dend2 (0), 1
    dend1 connect dend3 (0), 1

    dend0 {
    nseg = 10 
    diam = 2
    L = 1000 
	  }
    dend1 {
    nseg = 10 
    diam = 2
    L = 2000 
	  }
    dend2 {
    nseg = 10 
    diam = 1
    L = 500 
	  }
    dend3 {
    nseg = 10 
    diam = 2
    L = 500 
	  }
	  
   }
   
geometry()


proc geometry() { 

	/* NULL geometry procedure: keeps the user from
	calling the geometry procedure in isolation. */

    printf("\nYou must re-read the entire geometry\n")
    printf("file to execute geometry().\n\n")
}


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