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AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)
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Accession:
135839
This simple axon-soma model explained how the rapid rising phase in the somatic spike is derived from the propagated axon initiated spike, and how the somatic spike threshold variance is affected by spike propagation.
References:
1 .
McCormick DA, Shu Y, Yu Y (2007) Neurophysiology: Hodgkin and Huxley model--still standing?
Nature
445
:E1-2; discussion E2-3
[
PubMed
]
2 .
Yu Y, Shu Y, McCormick DA (2008) Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics.
J Neurosci
28
:7260-72
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Axon;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Channel(s):
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I_AHP;
Gap Junctions:
Receptor(s):
GabaA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Detailed Neuronal Models;
Implementer(s):
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
GabaA
;
NMDA
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I_AHP
;
/
McCormickEtAl2007YuEtAl2008
readme.txt
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for_plot_spike.m
mosinit.hoc
neuron_soma.dat
Rapid_rising_somatic_spike_soma_axon.hoc
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