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Selective control of cortical axonal spikes by a slowly inactivating K+ current (Shu et al. 2007)
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We discovered a low-threshold, slowly inactivating K+ current, containing Kv1.2 alpha subunits, in axon initial segment, playing a key role in the modulation of spike threshold and spike duration as well as the spike timing in prefrontal cortex layer V pyramidal cell of ferrets and rats. A kd.mod file implements this D current and put it in the axonal model: Neuron_Dcurrent.hoc. Run the model to see the gradual modulation effect over seconds on spike shape.
Shu Y, Yu Y, Yang J, McCormick DA (2007) Selective control of cortical axonal spikes by a slowly inactivating K+ current.
Proc Natl Acad Sci U S A
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Neuron or other electrically excitable cell;
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Action Potential Initiation;
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Neocortex L5/6 pyramidal GLU cell
Neocortex L2/3 pyramidal GLU cell
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