Superior paraolivary nucleus neuron (Kopp-Scheinpflug et al. 2011)

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Accession:139657
This is a model of neurons in the brainstem superior paraolivary nucleus (SPN), which produce very salient offset firing during sound stimulation. Rebound offset firing is triggered by IPSPs coming from the medial nucleus of the trapezoid body (MNTB). This model shows that AP firing can emerge from inhibition through integration of large IPSPs, driven by an extremely negative chloride reversal potential, combined with a large hyperpolarization- activated non-specific cationic current (IH), with a secondary contribution from a T-type calcium conductance (ITCa). As a result, tiny gaps in sound stimuli of just 3-4ms can elicit reliable APs that signal such brief offsets.
Reference:
1 . Kopp-Scheinpflug C, Tozer AJ, Robinson SW, Tempel BL, Hennig MH, Forsythe ID (2011) The sound of silence: ionic mechanisms encoding sound termination. Neuron 71:911-25 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Superior paraolivary nucleus neuron;
Channel(s): I T low threshold; I h;
Gap Junctions:
Receptor(s): Glycine;
Gene(s): HCN Cnga1;
Transmitter(s): Glycine;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Action Potentials; Rebound firing;
Implementer(s): Hennig, Matthias H [mhhennig at gmail.com];
Search NeuronDB for information about:  Glycine; I T low threshold; I h; Glycine;
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Kopp-Scheinpflug2011
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ht.mod *
lt.mod *
lva.mod
mhh_Gfluct.mod
netstims.mod *
sjg_ih.mod
sjg_na.mod
trigstim.mod *
allgraphs.hoc
conductance_noise.hoc
current_inj.hoc
mosinit.hoc
run_spn_model.hoc
simcontrols.hoc
spn_neuron.hoc
spnmodel1.png
synapses.hoc
                            
load_file("nrngui.hoc")
load_file("run_spn_model.hoc")

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