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Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
 
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Accession:
141505
This model is an extension of a model ( http://modeldb.yale.edu/138379 ) recently published in Frontiers in Computational Neuroscience. This model consists of 4700 event-driven, rule-based neurons, wired according to anatomical data, and driven by both white-noise synaptic inputs and a sensory signal recorded from a rat thalamus. Its purpose is to explore the effects of cortical damage, along with the repair of this damage via a neuroprosthesis.
Reference:
1 .
Kerr CC, Neymotin SA, Chadderdon GL, Fietkiewicz CT, Francis JT, Lytton WW (2012) Electrostimulation as a prosthesis for repair of information flow in a computer model of neocortex.
IEEE Trans Neural Syst Rehabil Eng
20
:153-60
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Neocortex V1 interneuron basket PV GABA cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiny stellate cell;
Channel(s):
I Chloride;
I Sodium;
I Potassium;
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Gaba;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Deep brain stimulation;
Information transfer;
Brain Rhythms;
Implementer(s):
Lytton, William [bill.lytton at downstate.edu];
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Kerr, Cliff [cliffk at neurosim.downstate.edu];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
Neocortex V1 interneuron basket PV GABA cell
;
GabaA
;
AMPA
;
NMDA
;
Gaba
;
I Chloride
;
I Sodium
;
I Potassium
;
Gaba
;
Glutamate
;
/
neuroprosthesis
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