Advanced search
SenseLab
SimToolDB
ModelDB Help
User account
Login
Register
Find models by
Model name
First author
Each author
Region(circuits)
Find models for
Cell type
Current
Receptor
Gene
Transmitters
Concept
Simulators
Methods
Find models of
Realistic Networks
Neurons
Electrical synapses (gap junctions)
Chemical synapses
Ion channels
Neuromuscular junctions
Axons
Pathophysiology
Other resources
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Two Models for synaptic input statistics for the MSO neuron model (Jercog et al. 2010)
 
Download zip file
Help downloading and running models
Model Information
Model File
Citations
Accession:
141991
The model is a point neuron model with ionic currents from Rothman & Mannis (2003) and with an update of the low threshold potassium current (IKLT) measured in-vitro by Mathews & Jercog et al (2010). This model in conjunction with the synaptic input models presented here has been used to gain insight into mechanisms that account for experimentally observed asymmetries in ITD tuning (Brand et al, 2002). Asymmetry and displacement of the ITD response function is achieved in the model by the interplay between asymmetry of the excitatory inputs arriving from the two sides and the precise voltage dependent activation of IKLT. In Jercog et al (2010) we propose two different mathematical ways, physiologically plausible scenarios, of generating the asymmetry in the bilateral synaptic input events. Here, we present two models for simulating the stochastic synaptic input trains.
Reference:
1 .
Jercog PE, Svirskis G, Kotak VC, Sanes DH, Rinzel J (2010) Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system.
PLoS Biol
8
:e1000406
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Axon;
Brain Region(s)/Organism:
Cell Type(s):
Medial Superior Olive (MSO) cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
C or C++ program;
Model Concept(s):
Synaptic-input statistic;
Audition;
Implementer(s):
Jercog, Pablo [pjercog at gmail.com];
Download the displayed file
/
Two_Models
README.rtf
README.txt
Carney-like_syn-inp_model2.c
Carney-like_syn-inp_model2__Figure1.eps
Carney-like_syn-inp_model2__Figure2.eps
Gauss-jittered__syn-inp_model1.c
Gauss-jittered__syn-inp_model1_frozen-IKLT.c
Gauss-jittered__syn-inp_model1_three-diff-cases.eps
Gauss-jittered__syn-inp_model1_three-diff-frequencies.eps
Gauss-jittered__syn-inp_model1_w-inh.c
ModelDB scripts have detected that binary file '/Two_Models/Gauss-jittered__syn-inp_model1_three-diff-frequencies.eps' is not displayable. You may download the file to examine if desired.
<- Select file from this column.
Loading data, please wait...