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Compartmentalization of GABAergic inhibition by dendritic spines (Chiu et al. 2013)

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Accession:143604
A spiny dendrite model supports the hypothesis that only inhibitory inputs on spine heads, not shafts, compartmentalizes inhibition of calcium signals to spine heads as seen in paired inhibition with back-propagating action potential experiments on prefrontal cortex layer 2/3 pyramidal neurons in mouse (Chiu et al. 2013).
Reference:
1 . Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ (2013) Compartmentalization of GABAergic inhibition by dendritic spines. Science 340:759-62 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I K;
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Influence of Dendritic Geometry;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; GabaA; I Na,t; I L high threshold; I K;
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singleDendrite
mod
ca.mod
ca_a1g.mod
ca_a1h.mod *
cad.mod
constant.mod
distr.mod *
exp2syncur.mod
exp2synsat.mod
im.mod *
kca.mod *
km.mod *
kv.mod
multiclamp.mod
na.mod
zoidsyn.mod *
                            
TITLE slowly activating potassium current (M-current)

COMMENT
        *********************************************
        reference:   	Yamada, Koch & Adams (1989) 
			Methods in Neuronal Modeling, MIT press
        found in:       bullfrog sympathetic ganglion cells
        *********************************************
	Assembled for MyFirstNEURON by Arthur Houweling
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	SUFFIX iM
	USEION k READ ek WRITE ik 
        RANGE gkbar, m_inf, tau_m, ik
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
	v		(mV)
	celsius		(degC)
        dt              (ms)
	ek		(mV)
	gkbar= 0.00031	(mho/cm2)
:	gkbar= 0.0006	(mho/cm2)
}

STATE {
	m
}

ASSIGNED {
	ik		(mA/cm2)
	m_inf
	tau_m		(ms)
	tau_h		(ms)
	tadj
}

BREAKPOINT { 
	SOLVE states :METHOD euler
:	ik = gkbar * m * (v-ek)
	ik = gkbar * m * (v+105)
}

:DERIVATIVE states {
:       evaluate_fct(v)
:
:       m'= (m_inf-m) / tau_m 
:}
  
PROCEDURE states() {
        evaluate_fct(v)

        m= m + (1-exp(-dt/tau_m))*(m_inf-m)
}

UNITSOFF
INITIAL {
:	tadj = 2.3^((celsius-23)/10)
	tadj = 3^((celsius-23.5)/10)
	evaluate_fct(v)
	m = m_inf
}

PROCEDURE evaluate_fct(v(mV)) {  LOCAL a,b
	tau_m = 1000.0/(3.3*(exp((v+35)/20)+exp(-(v+35)/20))) / tadj
	m_inf = 1.0 / (1+exp(-(v+35)/10))
}
UNITSON

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