Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)

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Accession:144372
Three models of increasing complexity all showing a switch from type II (biphasic) to type I (monophasic) phase response curves with a cholinergic down-modulation of K+ conductances.
Reference:
1 . Stiefel KM, Gutkin BS, Sejnowski TJ (2009) The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons. J Comput Neurosci 26:289-301 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I M;
Gap Junctions:
Receptor(s): Muscarinic;
Gene(s):
Transmitter(s): Acetylcholine;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Stiefel, Klaus [stiefel at salk.edu];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; Muscarinic; I Na,p; I Na,t; I M; Acetylcholine;
 
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StiefelEtAl2009
                            
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