Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)

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Accession:144579
Using the Traub et al (2005) model of the cortex we determined how 33 synaptic strength parameters control gamma oscillations. We used fractional factorial design to reduce the number of runs required to 4096. We found an expected multiplicative interaction between parameters.
Reference:
1 . Chambers JD, Bethwaite B, Diamond NT, Peachey T, Abramson D, Petrou S, Thomas EA (2012) Parametric computation predicts a multiplicative interaction between synaptic strength parameters that control gamma oscillations. Front Comput Neurosci 6:53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Axon; Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s): I A; I K; I K,leak; I K,Ca; I Calcium; I_K,Na;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Parameter sensitivity;
Implementer(s): Thomas, Evan [evan at evan-thomas.net]; Chambers, Jordan [jordandchambers at gmail.com];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; GabaA; AMPA; NMDA; I A; I K; I K,leak; I K,Ca; I Calcium; I_K,Na; Gaba; Glutamate;
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FRBGamma
cells
data
hoc
mod
net
README
balanal.hoc *
balcomp.hoc *
cell_templates.hoc *
des2runs.py
EFP2PSD.m
EFPgen.m
evan.hoc
finit.hoc *
fortmap.hoc *
FRBGamm.val
FRBGamma.des
gidcell.hoc *
manage_setup.hoc
singleoutput.m
spkplt.hoc *
synstrengthdef.hoc
                            
objref fih0_, fih1_
fih0_ = new FInitializeHandler(0, "finit0()")
fih1_ = new FInitializeHandler(1, "finit1()")

proc finit0() { local i, gid, ix  localobj cell
	for pcitr(&i, &gid, 1) {
		cell = pc.gid2cell(gid)
		ix = cell.type()
		forsec cell.all { v = type_vinit.x[ix] }
		// but for TCR, states are initialized at -85
		if (ix == TCRtype) {
			forsec cell.all { v = -85 }
		}
	}
}

proc finit1() { local i, gid, ix  localobj cell
	// special handling for TCR voltage initialization
	for pcitr(&i, &gid, 1) {
		cell = pc.gid2cell(gid)
		ix = cell.type
		if (ix == TCRtype) {
			forsec cell.all { v = type_vinit.x[ix] }
		}
	}
}

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