Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)

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Accession:144579
Using the Traub et al (2005) model of the cortex we determined how 33 synaptic strength parameters control gamma oscillations. We used fractional factorial design to reduce the number of runs required to 4096. We found an expected multiplicative interaction between parameters.
Reference:
1 . Chambers JD, Bethwaite B, Diamond NT, Peachey T, Abramson D, Petrou S, Thomas EA (2012) Parametric computation predicts a multiplicative interaction between synaptic strength parameters that control gamma oscillations. Front Comput Neurosci 6:53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Axon; Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s): I A; I K; I K,leak; I K,Ca; I Calcium; I_K,Na;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Parameter sensitivity;
Implementer(s): Thomas, Evan [evan at evan-thomas.net]; Chambers, Jordan [jordandchambers at gmail.com];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; GabaA; AMPA; NMDA; I A; I K; I K,leak; I K,Ca; I Calcium; I_K,Na; Gaba; Glutamate;
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FRBGamma
hoc
balcomp.hoc *
defvar.hoc *
lbcreate.hoc *
mscreate.hoc *
parlib.hoc
parlib_traub.hoc
parlib2.hoc
traubcon.hoc *
traubcon_net.hoc *
                            
{load_file("stdlib.hoc")}
proc default_var() {localobj s, pc
	s = new String()
	if (name_declared($s1) == 0) {
		if (argtype(2) == 2) {
			sprint(s.s, "~strdef %s", $s1)
			execute(s.s)
			sprint(s.s, "%s = \"%s\"", $s1, $s2)
		}else{
			hoc_ac_ = $2
			sprint(s.s, "%s = hoc_ac_", $s1)
		}
		execute(s.s)
	}
	pc = new ParallelContext()
	if (pc.id == 0) {
		sprint(s.s, "print \"%s  \", %s", $s1, $s1)
		execute(s.s)
	}
}


// BlueGene has an occasional system error with respect to
// incessantly changing directories with load_file
// following should work as long as nothing loaded twice
// and only used for files relative to the project
strdef curdir
curdir = "./"
proc localloadfile() {localobj dir, f, sf, oldcd, path
//	load_file($s1)
//	return

	oldcd = new String()
	oldcd.s = curdir

	sf = new StringFunctions()
	dir = new String()
	path = new String()
	f = new String()
	i = sf.head($s1, "/[^/]*$", dir.s)
	f.s = $s1
	if (i == -1) {
		dir.s = ""
	}else{
		sprint(dir.s, "%s/", dir.s)
		sf.right(f.s, i+1)
	}
	sprint(curdir, "%s%s", curdir, dir.s)
	sprint(path.s, "%s%s", curdir, f.s)
//printf("loading %s\n", path.s)
	xopen(path.s)
	curdir = oldcd.s
}

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