Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)

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These models predict the differential effects of varying pathways of inactivation (closed state inactivation, CSI, or open state inactivation, OSI). Specifically, Markov models of Kv4 potassium channels with CSI or CSI+OSI were inserted into the CA1 pyramidal neuron model from Migliore et al (1999; ModelDB accession #2796) to determine the neurophysiological impact of inactivation pathways. Furthermore, Markov models of Kv4.2 and Kv3.4 channels are used to illustrate a method by which to test what pathway of inactivation a channel uses.
1 . Fineberg JD, Ritter DM, Covarrubias M (2012) Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels. J Gen Physiol 140:513-27 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Gene(s): Kv4.2 KCND2; Kv3.4 KCNC4;
Simulation Environment: NEURON; IonChannelLab;
Model Concept(s): Ion Channel Kinetics; Markov-type model;
Implementer(s): Ritter, David [david.ritter at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,t; I A; I K;
IonChannelLab is available at:
For more information on the program see De Santiago Castillo et al. Channels (2010).

The .ichl files contain the schemes, parameters and simulations used.  The interface 
contains two areas:
1)Kinetic modeling - schemes and parameters
2)Simulations - where experiments are run

There may be some need to change sampling intervals or number of sweeps in the double 
pulse protocols to get the full resolution.  Simulations may be saved as a .txt file 
by clicking the save button and selecting simulation.  To recreate figure 2, there will 
be a need to save each SSI and current family before switching the lambda1 (kio) value 
and repeating.

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