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Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)
 
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Model Information
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Accession:
147867
These simulations examined the atrophy induced changes in electrophysiological properties of CA3 pyramidal neurons. We found these neurons change from bursting to regular spiking as atrophy increases. Region-specific atrophy induced region-specific increases in synaptic excitability in a passive dendritic tree. All dendritic compartments of an atrophied neuron had greater synaptic excitability and a larger voltage transfer to the soma than the control neuron.
Reference:
1 .
Narayanan R, Chattarji S (2010) Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus.
J Neurophysiol
103
:3070-83
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Synapse;
Dendrite;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA3 pyramidal GLU cell;
Channel(s):
I Na,t;
I L high threshold;
I N;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
I_AHP;
Gap Junctions:
Receptor(s):
AMPA;
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Active Dendrites;
Influence of Dendritic Geometry;
Detailed Neuronal Models;
Action Potentials;
Conductance distributions;
Implementer(s):
Narayanan, Rishikesh [rishi at iisc.ac.in];
Search NeuronDB
for information about:
Hippocampus CA3 pyramidal GLU cell
;
AMPA
;
I Na,t
;
I L high threshold
;
I N
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
I_AHP
;
Glutamate
;
/
CA3Atrophy
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0% Atrophy
25% Atrophy
35% Atrophy
75% Atrophy
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