Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Roles of essential kinases in induction of late hippocampal LTP (Smolen et al., 2006)
Download zip file
Help downloading and running models
"… Convergence of multiple kinase activities to induce L-LTP helps to generate a threshold whereby the amount of L-LTP varies steeply with the number of brief (tetanic) electrical stimuli. The model simulates tetanic, -burst, pairing-induced, and chemical L-LTP, as well as L-LTP due to synaptic tagging. The model also simulates inhibition of L-LTP by inhibition of MAPK, CAMKII, PKA, or CAMKIV. The model predicts results of experiments to delineate mechanisms underlying L-LTP induction and expression. …"
Smolen P, Baxter DA, Byrne JH (2006) A model of the roles of essential kinases in the induction and expression of late long-term potentiation.
(Click on a link to find other models with that property)
Hippocampus CA1 pyramidal GLU cell;
Long-term Synaptic Plasticity;
Byrne, John [john.h.byrne at uth.tmc.edu];
Smolen, Paul [paul.d.smolen at uth.tmc.edu];
for information about:
Hippocampus CA1 pyramidal GLU cell
File not selected
<- Select file from this column.
Loading data, please wait...