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KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)
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Accession:
150024
The output of the cerebellum to the motor axis of the central nervous system is orchestrated mainly by synaptic inputs and intrinsic pacemaker activity of deep cerebellar nuclear (DCN) projection neurons. Herein, we demonstrate that the soma of these cells is enriched with KV1 channels produced by mandatory multi-merization of KV1.1, 1.2 alpha andKV beta2 subunits. Being constitutively active, the K+ current (IKV1) mediated by these channels stabilizes the rate and regulates the temporal precision of self-sustained firing of these neurons. ... Through the use of multi-compartmental modelling and ... the physiological significance of the described functions for processing and communication of information from the lateral DCN to thalamic relay nuclei is established.
Reference:
1 .
Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO (2013) A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.
J Physiol
591
:1771-91
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Cerebellum deep nucleus neuron;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I K;
I h;
I CAN;
I_Ks;
Gap Junctions:
Receptor(s):
AMPA;
NMDA;
Gene(s):
Kv1.1 KCNA1;
Kv1.2 KCNA2;
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Bursting;
Ion Channel Kinetics;
Active Dendrites;
Detailed Neuronal Models;
Intrinsic plasticity;
Rebound firing;
Implementer(s):
Steuber, Volker [v.steuber at herts.ac.uk];
Luthman, Johannes [jwluthman at gmail.com];
Search NeuronDB
for information about:
AMPA
;
NMDA
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I K
;
I h
;
I CAN
;
I_Ks
;
/
CNModel_May2013
readme.txt
CaConc.mod
*
Other models using CaConc.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
CaHVA.mod
*
Other models using CaHVA.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
CalConc.mod
*
Other models using CalConc.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
CaLVA.mod
*
Other models using CaLVA.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
DCNsyn.mod
*
Other models using DCNsyn.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
DCNsynGABA.mod
*
Other models using DCNsynGABA.mod:
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
DCNsynNMDA.mod
*
Other models using DCNsynNMDA.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
fKdr.mod
*
Other models using fKdr.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
GammaStim.mod
*
Other models using GammaStim.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
h.mod
*
Other models using h.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
Ifluct8.mod
*
Other models using Ifluct8.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
NaF.mod
*
Other models using NaF.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
NaP.mod
*
Other models using NaP.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
pasDCN.mod
*
Other models using pasDCN.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
SK.mod
*
Other models using SK.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
sKdr.mod
*
Other models using sKdr.mod:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
TNC.mod
*
Other models using TNC.mod:
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
DCN_cip_axis_main.hoc
DCN_cip_fi_main.hoc
DCN_mechs1.hoc
*
Other models using DCN_mechs1.hoc:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
DCN_mechs2.hoc
DCN_morph.hoc
*
Other models using DCN_morph.hoc:
Cerebellar nuclear neuron (Sudhakar et al., 2015)
STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
DCN_params.hoc
DCN_params_axis.hoc
DCN_params_fi_init.hoc
DCN_params_rebound.hoc
DCN_rebound_main.hoc
DCN_recording.hoc
DCN_spontact_loop_main.hoc
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