Auditory cortex layer IV network model (Beeman 2013)

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Accession:150678
"... The primary objective of this modeling study was to determine the effects of axonal conduction velocity (often neglected, but significant), as well as synaptic time constants, on the ability of such a network to create and propagate cortical waves. ... The model is also being used to study the interaction between single and two-tone input and normal background activity, and the effects of synaptic depression from thalamic inputs. The simulation scripts have the additional purpose of serving as tutorial examples for the construction of cortical networks with GENESIS. The present model has fostered the development of the G-3 Python network analysis and visualization tools used in this study... It is my hope that this short tutorial and the example simulation scripts can provide a head start for a graduate student or postdoc who is beginning a cortical modeling project. "
Reference:
1 . Beeman D (2013) A modeling study of cortical waves in primary auditory cortex BMC Neuroscience 14(Supl 1):P23
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Auditory cortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Tutorial/Teaching;
Implementer(s): Beeman, Dave;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; 
// layer5.p - Cell parameter file for the Bush and Sejnowski (1993)
// reduced 9 compartment layer 5 (deep) cortical pyramidal cell.

*relative
*cartesian
*asymmetric

// membrane constants (SI units)
*set_global        RM      0.7042     // ohm*m^2
*set_global        RA      2.0        // ohm*m
*set_global        CM      0.0284     // farad/m^2
*set_global     EREST_ACT  -0.066     // volts (leakage potential)

// Populate soma wih modified traub91 channels

soma    none  0  0 17 23 \
    Na_pyr             1200  \
    Kdr_pyr             800  \
    Ca_hip_traub91      100  \
    Kahp_pyr             25  \
    Ca_conc            -7.769e12    \
    spike 0.0

apical0 soma       0   0  50    7.2
apical2 apical0    0   0  325   5.4
apical3 apical2    0   0  360   3.2  AMPA_pyr 2.6526
apical4 apical3    0   0  240   2.0
apical1 apical0 -125   0   0    3.6  AMPA_pyr 2.6526
basal0  soma     0     0  -40   5.0  GABA_pyr 2.6526
basal1  basal0  99.0   0  -99.0 5.4  AMPA_pyr 5.0
basal2  basal0 -99.0    0 -99.0 5.4

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