Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)

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Accession:154732
"We use a computational model of a hippocampal CA1 pyramidal cell to demonstrate that spine head calcium provides an instantaneous readout at each synapse of the postsynaptic weighted sum of all presynaptic activity impinging on the cell. The form of the readout is equivalent to the functions of weighted, summed inputs used in neural network learning rules. Within a dendritic layer, peak spine head calcium levels are either a linear or sigmoidal function of the number of coactive synapses, with nonlinearity depending on the ability of voltage spread in the dendrites to reach calcium spike threshold. ..."
Reference:
1 . Graham BP, Saudargiene A, Cobb S (2014) Spine head calcium as a measure of summed postsynaptic activity for driving synaptic plasticity. Neural Comput 26:2194-222 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration;
Implementer(s): Graham, Bruce [B.Graham at cs.stir.ac.uk];
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GrahamEtAl2014
Results
SR_camaxav_spnum.dat
                            
20 0.00194761 7.65143e-06
40 0.00197885 1.47697e-05
60 0.00201635 2.26783e-05
80 0.00206342 2.89414e-05
100 0.00211205 3.57769e-05
120 0.00218431 5.28255e-05
140 0.00309694 0.000456862
160 0.00280207 0.000214022
180 0.00278484 0.000191837
200 0.00278287 0.000186691
220 0.00281974 0.000195716
240 0.00287756 0.000197621
260 0.00296301 0.000214589
280 0.0030549 0.000247231
300 0.00316011 0.000265949
320 0.00328298 0.000296344
340 0.00342336 0.000329591
360 0.00355581 0.000352316
380 0.00396051 0.000462048
400 0.00478899 0.000939945
420 0.00490644 0.000940636
440 0.00499741 0.000949852
460 0.00510335 0.000979554
480 0.00520557 0.00101035
500 0.00535463 0.00109662

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