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Gq coupled signaling pathways involved in striatal synaptic plasticity (Kim et al. 2013)
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Model of Gq coupled signaling pathways underlying synaptic plasticity in striatal medium spiny projection neurons. Reactions and diffusion are implemented stochastically in a dendrite with one or more diffusionally coupled spines. Simulations demonstrate that theta burst stimulation, which produces LTP, increases the ratio of PKC:2AG as compared to 20 Hz stimulation, which produces LTD.
Kim B, Hawes SL, Gillani F, Wallace LJ, Blackwell KT (2013) Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity.
PLoS Comput Biol
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Neostriatum medium spiny direct pathway GABA cell;
Blackwell, Avrama [avrama at gmu.edu];
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Neostriatum medium spiny direct pathway GABA cell
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