" ...
We then
introduce a minimal model that consists of learning at the parallel
fibers to Purkinje cells with the help of the climbing
fibers. Although the minimal model reproduces the behavior of the
wild-type animals and is analytically tractable, it fails at
reproducing the behavior of mutant mice and the electrophysiology
data. Therefore, we build a detailed model involving plasticity at the
parallel fibers to Purkinje cells' synapse guided by climbing fibers,
feedforward inhibition of Purkinje cells, and plasticity at the mossy
fiber to vestibular nuclei neuron synapse. The detailed model
reproduces both the behavioral and electrophysiological data of both
the wild-type and mutant mice and allows for experimentally testable
predictions.
"
Reference:
1 .
Clopath C, Badura A, De Zeeuw CI, Brunel N (2014) A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. J Neurosci 34:7203-15 [PubMed]
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