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Neuronal dendrite calcium wave model (Neymotin et al, 2015)
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Accession:
168874
"... We developed a reaction-diffusion model of an apical dendrite with diffusible inositol triphosphate (IP3 ), diffusible Ca2+, IP3 receptors (IP3 Rs), endoplasmic reticulum (ER) Ca2+ leak, and ER pump (SERCA) on ER. ... At least two modes of Ca2+ wave spread have been suggested: a continuous mode based on presumed relative homogeneity of ER within the cell; and a pseudo-saltatory model where Ca2+ regeneration occurs at discrete points with diffusion between them. We compared the effects of three patterns of hypothesized IP3 R distribution: 1. continuous homogeneous ER, 2. hotspots with increased IP3R density (IP3 R hotspots), 3. areas of increased ER density (ER stacks). All three modes produced Ca2+ waves with velocities similar to those measured in vitro (~50 - 90µm /sec). ... The measures were sensitive to changes in density and spacing of IP3 R hotspots and stacks. ... An extended electrochemical model, including voltage gated calcium channels and AMPA synapses, demonstrated that membrane priming via AMPA stimulation enhances subsequent Ca2+ wave amplitude and duration. Our modeling suggests that pharmacological targeting of IP3 Rs and SERCA could allow modulation of Ca2+ wave propagation in diseases where Ca2+ dysregulation has been implicated. "
Reference:
1 .
Neymotin SA, McDougal RA, Sherif MA, Fall CP, Hines ML, Lytton WW (2015) Neuronal calcium wave propagation varies with changes in endoplasmic reticulum parameters: a computer model.
Neural Comput
27
:898-924
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Hippocampus CA3 pyramidal GLU cell;
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Channel(s):
I T low threshold;
I A;
I K;
I K,Ca;
I CAN;
I Sodium;
I Calcium;
I_SERCA;
I_KD;
Ca pump;
Gap Junctions:
Receptor(s):
AMPA;
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Calcium waves;
Reaction-diffusion;
Implementer(s):
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
McDougal, Robert [robert.mcdougal at yale.edu];
Sherif, Mohamed [mohamed.sherif.md at gmail.com];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
Hippocampus CA3 pyramidal GLU cell
;
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
AMPA
;
I T low threshold
;
I A
;
I K
;
I K,Ca
;
I CAN
;
I Sodium
;
I Calcium
;
I_SERCA
;
I_KD
;
Ca pump
;
Glutamate
;
/
ca1dDemo
data
readme.txt
cagk.mod
*
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cal_mig.mod
can_mig.mod
cat_mig.mod
kaprox.mod
*
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kdrca1.mod
*
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km.mod
*
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misc.mod
*
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In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
na3n.mod
*
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naf.mod
NMDA.mod
stats.mod
*
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vecst.mod
*
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Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
AMPA0.cfg
AMPA150.cfg
analysisCode.py
batch.py
cawave.cfg
cawave.py
conf.py
geneval_cvode.inc
*
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*
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netcon.inc
*
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nqs.hoc
nqs.py
plot_fig11.py
setup.hoc
*
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Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
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vector.py
*
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Fig 11 AMPA 0
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