TITLE E calcium current
 
COMMENT
  from "An Active Membrane Model of the Cerebellar Purkinje Cell
        1. Simulation of Current Clamp in Slice"
ENDCOMMENT
 
UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
}
 
NEURON {
        SUFFIX CaE
        USEION ca READ cai, cao WRITE ica
        RANGE  gcabar, ica, gca, minf, hinf, mexp, hexp
} 
 
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
 
PARAMETER {
        v (mV)
        celsius = 37 (degC)
        dt (ms)
        gcabar = .0005 (mho/cm2)
        eca = 135 (mV)
	cai	= 0.40e-4 (mM)		: adjusted for eca=135mV
	cao	= 2.4	(mM)

}
 
STATE {
        m h
}
 
ASSIGNED {
        ica (mA/cm2)
        gca minf hinf mexp hexp 
}
 
BREAKPOINT {
        SOLVE states
        gca = gcabar * m*h
	ica = gca* (v-eca)
}
 
UNITSOFF
 
INITIAL {
	rates(v)
	m = minf
	h = hinf
}

PROCEDURE states() {  :Computes state variables m, h
        rates(v)      :             at the current v and dt.
        m = m + mexp*(minf-m)
        h = h + hexp*(hinf-h)
}
 
PROCEDURE rates(v) {  :Computes rate and other constants at current v.
                      :Call once from HOC to initialize inf at resting v.
        LOCAL  q10, tinc, alpha, beta, sum
        TABLE minf, mexp, hinf, hexp DEPEND dt, celsius FROM -100 TO 100 WITH 200
        q10 = 3^((celsius - 37)/10)
        tinc = -dt * q10
                :"m" calcium activation system
        alpha = 2.6/(1+exp((v+7)/(-8)))
        beta =  0.18/(1+exp((v+26)/4))
        sum = alpha + beta
        minf = alpha/sum
        mexp = 1 - exp(tinc*sum/4)
                :"h" calcium inactivation system
        alpha = 0.0025/(1+exp((v+32)/8))
        beta = 0.19/(1+exp((v+42)/(-10)))
        sum = alpha + beta
        hinf = alpha/sum
        hexp = 1 - exp(tinc*sum/10)
}

 
UNITSON