Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:17664
We adopted De Schutter and Bower's model as the starting point, then modified the descriptions of several ion channels, such as the P-type Ca channel and the delayed rectifier K channel, and added class-E Ca channels and D-type K channels to the model. Our new model reproduces most of our experimental results and supports the conclusions of our experimental study that class-E Ca channels and D-type K channels are present and functioning in the dendrites of Purkinje neurons.
Reference:
1 . Miyasho T, Takagi H, Suzuki H, Watanabe S, Inoue M, Kudo Y, Miyakawa H (2001) Low-threshold potassium channels and a low-threshold calcium channel regulate Ca2+ spike firing in the dendrites of cerebellar Purkinje neurons: a modeling study. Brain Res 891:106-15 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): I Na,p; I Na,t; I T low threshold; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; I_KD;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Bursting; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Calcium dynamics;
Implementer(s): Miyakawa, H [Miyakawa at ls.toyaku.ac.jp];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I Na,p; I Na,t; I T low threshold; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; I_KD;
/
prknj
readme
CaE.mod *
CalciumP.mod *
CaP.mod *
CaP2.mod *
CaT.mod *
K2.mod *
K22.mod *
K23.mod *
KA.mod *
KC.mod *
KC2.mod *
KC3.mod *
KD.mod *
Kdr.mod *
Kh.mod *
Khh.mod *
KM.mod *
Leak.mod *
NaF.mod *
NaP.mod *
mosinit.hoc
purkinje.hoc
purkinje.ses
                            
TITLE Persistent potassium current
 
COMMENT
  from "An Active Membrane Model of the Cerebellar Purkinje Cell
        1. Simulation of Current Clamp in Slice"
ENDCOMMENT
 
UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
}
 
NEURON {
        SUFFIX KM
	USEION k  WRITE ik
        RANGE  gkbar, gk, minf,  mexp
} 
 
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
 
PARAMETER {
        v (mV)
        celsius = 37 (degC)
        dt (ms)
        gkbar	= .00004 (mho/cm2)
        ek	= -85 (mV)

}
 
STATE {
        m 
}
 
ASSIGNED {
        ik (mA/cm2)
        gk minf  mexp 
}
 
BREAKPOINT {
        SOLVE states
        gk = gkbar *m
	ik = gk* (v-ek)
}
 
UNITSOFF
 
INITIAL {
	rates(v)
	m = minf
	
}

PROCEDURE states() {  :Computes state variables m
        rates(v)      :             at the current v and dt.
        m = m + mexp*(minf-m)
}
 
PROCEDURE rates(v) {  :Computes rate and other constants at current v.
                      :Call once from HOC to initialize inf at resting v.
        LOCAL  q10, tinc, sum
        TABLE minf, mexp DEPEND dt, celsius FROM -100 TO 100 WITH 200
        q10 = 3^((celsius - 37)/10)
        tinc = -dt * q10
                :"m" potassium activation system
        sum = 3.3*(exp((v+35)/40)+exp(-(v+35)/20))/200
        minf = 1.0 / (1+exp(-(v+35)/10))
        mexp = 1 - exp(tinc*sum)
               
}

 
UNITSON


Loading data, please wait...