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TRPM8-dependent dynamic response in cold thermoreceptors (Olivares et al. 2015)

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Accession:182988
This model reproduces the dynamic response of cold thermoreceptors, transiently changing the firing rate upon heating or cooling. It also displays the 'static' or adapted firing patterns observed in these receptors.
Reference:
1 . Olivares E, Salgado S, Maidana JP, Herrera G, Campos M, Madrid R, Orio P (2015) TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor. PLoS One 10:e0139314 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Dorsal Root Ganglion (DRG) cell; Dorsal Root Ganglion cell: cold sensing;
Channel(s): I Na,p; I Na,t; I K; I K,Ca; I trp; I TRPM8;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Bursting; Temporal Pattern Generation; Oscillations; Homeostasis; Temperature; Sensory coding;
Implementer(s): Orio, Patricio [patricio.orio at uv.cl];
Search NeuronDB for information about:  I Na,p; I Na,t; I K; I K,Ca; I trp; I TRPM8;
 
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