Discharge hysteresis in motoneurons (Powers & Heckman 2015)

 Download zip file 
Help downloading and running models
Accession:183949
"Motoneuron activity is strongly influenced by the activation of persistent inward currents (PICs) mediated by voltage-gated sodium and calcium channels. ... It has recently been suggested that a number of factors other than PIC can contribute to delta F (firing rate differences between motoneurons) values, including mechanisms underlying spike frequency adaptation and spike threshold accommodation. In the present study, we used a set of compartmental models representing a sample of 20 motoneurons with a range of thresholds to investigate how several different intrinsic motoneuron properties can potentially contribute to variations in F values. ... Our results indicate that, although other factors can contribute, variations in discharge hysteresis and delta F values primarily reflect the contribution of dendritic PICs to motoneuron activation.
Reference:
1 . Powers RK, Heckman CJ (2015) Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study. J Neurophysiol 114:184-98 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I K; I M; I K,Ca; I_AHP; I Calcium; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.2 KCNA2; Kv1.9 Kv7.1 KCNQ1;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Spike Frequency Adaptation;
Implementer(s): Powers, Randy [rkpowers at u.washington.edu];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I L high threshold; I K; I M; I K,Ca; I Sodium; I Calcium; I_AHP;
6007.0000
6147.1000
6289.0500
6409.3250
6523.9250
6624.7750
6730.8750
6826.2500
6917.7250
7011.2750
7099.9750
7186.8750
7266.9500
7349.5000
7429.6000
7500.9250
7577.5000
7652.6750
7727.6250
7801.3500
7868.1250
7936.0250
8001.7000
8068.4750
8133.9750
8198.4500
8260.9250
8325.9750
8388.4250
8450.0500
8511.7500
8571.4250
8630.7500
8689.3500
8746.5000
8803.2250
8860.3750
8915.8500
8972.9750
9028.4500
9083.7500
9137.8750
9191.5000
9244.2000
9297.2000
9349.6000
9401.7500
9452.6500
9504.8000
9555.3250
9606.4250
9656.7250
9705.8250
9755.4500
9804.4250
9852.3750
9900.3750
9949.5000
9998.1000
10046.9000
10093.4500
10140.2750
10187.9250
10234.8000
10280.1000
10325.9750
10371.6000
10416.5250
10462.2750
10508.1500
10553.4250
10597.8250
10643.0250
10687.2500
10730.0500
10774.2750
10817.8500
10861.3000
10903.9500
10947.7750
10990.6750
11033.1500
11076.3250
11118.4250
11162.1000
11205.4500
11249.6250
11291.8750
11336.5750
11380.6250
11425.5250
11469.9500
11514.7500
11560.1500
11604.8500
11650.1500
11695.3000
11741.3500
11788.3250
11834.3750
11881.0250
11928.3750
11975.1250
12023.3500
12070.2750
12117.7500
12167.6000
12217.0750
12265.5250
12316.1250
12366.0750
12416.3250
12465.8750
12517.8500
12568.3250
12620.1750
12671.6000
12724.2500
12777.0250
12829.5500
12883.0000
12936.9500
12992.6500
13047.4500
13102.6750
13158.9250
13217.0750
13273.4500
13329.9500
13387.9000
13447.5750
13507.7750
13566.7250
13628.7500
13689.1250
13752.0750
13814.2000
13879.8750
13943.7250
14011.1250
14078.0000
14146.1750
14215.3250
14288.8250
14360.7250
14434.1250
14509.5250
14588.1250
14665.8000
14747.1500
14826.6500
14914.5250
15004.7500
15099.3500
15197.8750
15291.6250
15399.4500
15515.7000
15641.0000
15786.5250
15951.0000
16150.0000


Loading data, please wait...