Discharge hysteresis in motoneurons (Powers & Heckman 2015)

 Download zip file 
Help downloading and running models
Accession:183949
"Motoneuron activity is strongly influenced by the activation of persistent inward currents (PICs) mediated by voltage-gated sodium and calcium channels. ... It has recently been suggested that a number of factors other than PIC can contribute to delta F (firing rate differences between motoneurons) values, including mechanisms underlying spike frequency adaptation and spike threshold accommodation. In the present study, we used a set of compartmental models representing a sample of 20 motoneurons with a range of thresholds to investigate how several different intrinsic motoneuron properties can potentially contribute to variations in F values. ... Our results indicate that, although other factors can contribute, variations in discharge hysteresis and delta F values primarily reflect the contribution of dendritic PICs to motoneuron activation.
Reference:
1 . Powers RK, Heckman CJ (2015) Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study. J Neurophysiol 114:184-98 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I K; I M; I K,Ca; I_AHP; I Calcium; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.2 KCNA2; Kv1.9 Kv7.1 KCNQ1;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Spike Frequency Adaptation;
Implementer(s): Powers, Randy [rkpowers at u.washington.edu];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I L high threshold; I K; I M; I K,Ca; I Sodium; I Calcium; I_AHP;
2192.6750
2366.7750
2521.8500
2660.6750
2784.4000
2897.4250
3001.8000
3095.4250
3182.4500
3260.2000
3332.9750
3404.1250
3473.9250
3542.6000
3610.0250
3676.2750
3742.1250
3806.3250
3870.0000
3932.1750
3994.1500
4055.8500
4115.4250
4174.4500
4232.9500
4290.8000
4347.6500
4403.1250
4458.6500
4513.7250
4568.6000
4622.0750
4675.6750
4729.1750
4782.3250
4835.0000
4887.4500
4939.4500
4991.5000
5041.7750
5092.9000
5144.3000
5195.1000
5244.5750
5295.3250
5345.5000
5395.6000
5445.3250
5493.3000
5541.8500
5590.7250
5638.7750
5686.7750
5734.7750
5783.6750
5831.7250
5879.1000
5925.9500
5973.0500
6020.6500
6066.5000
6113.7250
6159.2750
6206.2500
6252.3250
6297.9500
6344.3250
6390.2750
6436.3000
6480.8500
6525.7000
6569.9250
6614.8750
6659.6250
6705.1750
6749.2000
6794.4250
6838.6250
6882.2250
6925.3500
6968.8750
7012.5250
7055.8500
7098.9750
7142.1750
7185.0500
7228.7250
7270.9750
7314.3250
7356.6750
7399.2750
7442.2250
7484.1250
7525.9500
7568.4250
7611.6000
7653.6750
7695.1500
7736.8750
7778.5000
7820.1000
7860.9250
7902.9500
7944.5000
7985.6250
8026.4500
8068.2250
8108.7250
8151.2000
8190.2500
8231.3500
8273.3000
8313.6500
8353.9500
8394.1500
8433.5000
8474.5750
8515.3250
8555.4000
8595.7000
8636.9500
8676.3000
8716.3750
8755.9000
8795.3250
8834.5500
8874.6000
8913.7000
8952.9000
8992.1500
9031.0750
9070.9250
9109.1750
9148.9000
9187.1500
9226.2000
9264.1750
9305.0000
9343.1750
9381.5250
9420.2750
9458.5500
9496.9750
9536.0250
9574.5000
9612.4000
9651.0750
9688.1500
9725.3750
9764.2250
9801.0000
9838.5000
9878.0000
9914.9750
9953.7750
9990.1000
10028.1500
10065.8000
10103.5000
10140.9500
10178.3000
10215.6750
10253.5250
10292.4750
10328.9500
10365.5000
10403.2750
10440.3750
10477.5250
10514.6500
10551.0250
10588.2000
10623.9000
10660.7750
10697.1500
10732.3250
10769.3000
10804.8000
10842.5750
10879.2750
10915.5000
10951.5750
10986.6750
11024.1000
11059.9750
11095.3250
11132.2250
11170.5000
11206.2000
11243.1000
11279.8750
11316.0750
11352.9500
11390.5750
11427.3750
11463.4500
11500.6750
11536.3250
11573.3250
11610.8500
11647.9250
11685.7500
11722.1500
11760.8250
11798.6500
11837.7250
11875.0750
11912.9000
11949.9250
11988.1750
12025.6250
12064.1250
12101.4000
12140.1750
12177.6000
12216.7500
12254.4500
12291.6250
12330.5750
12368.8500
12407.6500
12446.5750
12484.8750
12523.9750
12562.5000
12600.7000
12639.0250
12678.9500
12718.4750
12756.8250
12795.6750
12835.4000
12875.1750
12914.7000
12953.3000
12993.2500
13031.4500
13072.2500
13112.5000
13152.3500
13192.0250
13231.3750
13272.2500
13310.8250
13351.4250
13392.6500
13432.5000
13472.7000
13512.9750
13554.0250
13595.0500
13635.2250
13675.1500
13716.3000
13757.3000
13797.8500
13839.4750
13880.6250
13922.1250
13963.9500
14004.4500
14046.0250
14086.9750
14128.6000
14171.4000
14212.2500
14253.1500
14295.4750
14337.6250
14379.7500
14420.5750
14462.7750
14505.6250
14547.7250
14590.3250
14633.8250
14676.9500
14720.2750
14763.4250
14806.3500
14850.4250
14893.0500
14936.0250
14980.1250
15023.5500
15067.0250
15110.7250
15155.3500
15200.0500
15244.4750
15289.0000
15332.5250
15377.3500
15422.3750
15467.0000
15512.4250
15557.1500
15603.1000
15648.6750
15694.1500
15740.7000
15786.9250
15833.3750
15878.9250
15926.1500
15972.5000
16019.6750
16066.3750
16113.7750
16161.7500
16209.6000
16257.2750
16305.3500
16353.2250
16403.0000
16451.4750
16500.5250
16548.4250
16598.5000
16648.5000
16698.3750
16748.0500
16798.3750
16849.4750
16900.2750
16950.8250
17002.1250
17053.5750
17106.4750
17157.2000
17209.9250
17262.4750
17316.1250
17368.8000
17423.3750
17477.2750
17531.5250
17586.3000
17641.1500
17697.6750
17753.5500
17809.7500
17866.7500
17924.4750
17981.5500
18041.0000
18100.1000
18158.7250
18220.1250
18281.7000
18344.3500
18406.0250
18469.9500
18534.6250
18600.0250
18667.0500
18735.1750
18804.3250
18874.9750
18946.7750
19019.6250
19094.9250
19171.1250
19248.4000
19326.7250
19407.2000
19488.5750
19571.3250
19655.5500
19741.4250
19828.7500
19917.6250
20010.3000
20104.3500
20201.2500
20303.0250
20410.6500
20532.3250


Loading data, please wait...