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CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
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Model Information
Model File
Citations
Accession:
184054
This model simulates the effects of dendritic sodium spikes initiated in distal apical dendrites on the voltage and the calcium dynamics revealed by calcium imaging. It shows that dendritic sodium spike promotes large and transient calcium influxes via NMDA receptor and L-type voltage-gated calcium channels, which contribute to the induction of LTP at distal synapses.
Reference:
1 .
Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N (2015) Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons.
Elife
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Synapse;
Channel/Receptor;
Dendrite;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I L high threshold;
I K;
Ca pump;
I Sodium;
Gap Junctions:
Receptor(s):
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Dendritic Action Potentials;
Ion Channel Kinetics;
Active Dendrites;
Detailed Neuronal Models;
Synaptic Plasticity;
Long-term Synaptic Plasticity;
Synaptic Integration;
Calcium dynamics;
Conductance distributions;
Implementer(s):
Cembrowski, Mark S [cembrowskim at janelia.hhmi.org];
Hsu, Ching-Lung [hsuc at janelia.hhmi.org];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
AMPA
;
NMDA
;
I L high threshold
;
I K
;
I Sodium
;
Ca pump
;
Glutamate
;
Download the displayed file
/
fullMorphCaLTP8
fullMorphCaLTP8
calH.mod
cdp.mod
id.mod
kad.mod
*
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CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
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Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
kap.mod
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CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
kdr.mod
*
Other models using kdr.mod:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
na3.mod
*
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CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
nmdaSyn.mod
spgen2.mod
analyseTBSCC.hoc
channelParameters.hoc
displayPanels.hoc
doTBSStimCC.hoc
getVoltageIntegral.hoc
init.hoc
initializationAndRun.hoc
morphology_ri06.nrn
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naceaxon.nrn
*
Other models using naceaxon.nrn:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
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plotTBSCC.hoc
preallocate.hoc
resetNSeg.hoc
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Other models using resetNSeg.hoc:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
runTBSCC.hoc
seclists.hoc
start.hoc
NEURON { SUFFIX id RANGE id1, id2, id3, id4, id5 } ASSIGNED { id1 id2 id3 id4 id5 }
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