ModelDB: Cell signaling/ion channel variability effects on neuronal response (Anderson, Makadia, et al. 2015)

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Cell signaling/ion channel variability effects on neuronal response (Anderson, Makadia, et al. 2015)

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Accession:185300

" ... We evaluated the impact of molecular variability in the expression of cell signaling components and ion channels on electrophysiological excitability and neuromodulation. We employed a computational approach that integrated neuropeptide receptor-mediated signaling with electrophysiology. We simulated a population of neurons in which expression levels of a neuropeptide receptor and multiple ion channels were simultaneously varied within a physiological range. We analyzed the effects of variation on the electrophysiological response to a neuropeptide stimulus. ..."
Reference:
1 . Anderson WD, Makadia HK, Vadigepalli R (2016) Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes. J Comput Neurosci 40:65-82 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Channel/Receptor; Molecular Network;
Brain Region(s)/Organism:
Cell Type(s):	Brainstem neuron;
Channel(s):	I L high threshold; I A; I K,Ca; I Sodium; I Potassium; Na/Ca exchanger; I_Na,Ca; I_KD;
Gap Junctions:
Receptor(s):	AT1R;
Gene(s):
Transmitter(s):	Angiotensin;
Simulation Environment:	MATLAB;
Model Concept(s):	Activity Patterns; Action Potentials; Signaling pathways; Spike Frequency Adaptation; Parameter sensitivity; Depolarization block; G-protein coupled; Conductance distributions; Bifurcation; Synaptic noise; Neuromodulation;
Implementer(s):	Makadia, Hirenkumar K [hiren.makadia at gmail.com]; Anderson, Warren D [warren.anderson at jefferson.edu]; Vadigepalli, Rajanikanth [Rajanikanth.Vadigepalli at jefferson.edu];